中文名称:

盐酸博来霉素

中文同义词:

盐酸博来霉素;博来霉素盐酸盐

英文名称:

Bleomycin hydrochloride

英文同义词:

bleomycinchlorhydrate;BleomycinA5/Pingyangmycin;BleomycinHCl;BLEOMYCIN HYDROCHLORIDES;BleoMycin A4A5 Hydrochloride;BLEOMYCIN HYDROCHLORIDE;Bleomycin hydrochloride USP/EP/BP

CAS号:

67763-87-5

分子式:

C50H71N16O21S2R.x(HCl)

分子量:

0

EINECS号:

相关类别:

抑制剂;化工原料

Mol文件:

Mol File

生物活性

Bleomycin hydrochloride 是一种 DNA 损伤剂，抑制 DNA 合成。Bleomycin hydrochloride 是一种抗肿瘤抗生素 (antibiotic)。

体外研究

Bleomycin is chosen as the best-studied micronucleus inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation. The IC 50 value of Bleomycin for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin; IC 50 values are 14.2±2.8 nM and 13.0±1.1 nM, respectively.

体内研究

Bleomycin treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study. Bleomycin (3.5-4.0 mg/kg; intra-tracheal) produces a statistically significant increase in lung hydroxyproline levels, and also increases right caudal lung lobe mass. Animal Model: Male Fischer 344 rats, 8-10 week old, weighing 150-250 g Dosage: 3.5-4 mg/kg Administration: Intra-tracheal Result: Body weights decreased by day 4 then increased by Day 7 through the end of the study.

Animal Model:

Male Fischer 344 rats, 8-10 week old, weighing 150-250 g

Dosage:

3.5-4 mg/kg

Administration:

Intra-tracheal

Result:

Body weights decreased by day 4 then increased by Day 7 through the end of the study.