中文同义词:
3-羟基-alpha-((甲基氨基)甲基)-苄醇;L-苯肾上腺素;L-去氧肾上腺素碱;苯福林武汉厂家;去羟肾上腺素;去氧肾上腺;新交感酚;新辛内井林
英文同义词:
(-)-m-hydroxy-alpha-(methylaminomethyl)benzylalcohol;(-)-m-oxedrine;(R)-3-Hydroxy-alpha-[(methylamino)methyl]benzenemethanol hydrochloride;(r)-benzenemethano;(r)-phenylephrine;Adrianol;Ak-dilate;Ak-nefrin
沸点
295.79°C (rough estimate)
密度
1.1222 (rough estimate)
折射率
-55.5 ° (C=5, 1mol/L HCl)
溶解度
Slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides.
酸度系数(pKa)
pKa 8.9 (Uncertain)
CAS 数据库
59-42-7(CAS DataBase Reference)
NIST化学物质信息
Benzenemethanol, 3-hydroxy-«alpha»-[(methylamino)methyl]-, (r)-(59-42-7)
生物活性
(R)-(-)-Phenylephrine是选择性的α1-肾上腺素受体激动剂，主要用作减充血剂。
体外研究
(R)-(-)-Phenylephrine is a selective α 1 -adrenoceptor agonist with pK i values of 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca( 2+ )/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis.
体内研究
Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α 1 -adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.
用途
拟肾上腺素药物，用于外科手术延长局部麻醉时间、鼻粘膜充血、急性低血压、感染中毒性及过敏性休克等症
危险类别码
22-36/37/38-41-37/38
毒害物质数据
59-42-7(Hazardous Substances Data)
毒性
LD50 oral in rat: 350mg/kg
