中文名称:

奥替尼啶盐酸盐

中文同义词:

奥替尼啶 奥克太啶(双盐酸盐);奥克太啶盐酸盐;奥替尼啶盐酸盐;奥替尼啶 二盐酸盐;奥替尼啶杂质;奥替尼啶,奥克太啶;奥替尼定盐酸盐;盐酸奥替尼啶

英文名称:

Octenidine dihydrochloride

英文同义词:

N,N-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride;N,N-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride;Octenidine hydrochloride;OCTENIDINE DIHYDROCHLORIDE;N,N-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride;N-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride;1-OctanaMine,N,N-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2);ocenidine dihydrochloride

CAS号:

70775-75-6

分子式:

C36H64Cl2N4

分子量:

623.82616

EINECS号:

274-861-8

相关类别:

原料药;医药原料;原料药;化妆品原料;抗菌;新型抗菌;医药原料药;合成;Amines;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;医药 抗菌剂;医用原料;医药化工原料;化工原料;化工中间体;原料

Mol文件:

70775-75-6.mol

熔点 

215-217℃

溶解度 

Soluble in dimethyl sulfoxide and methanol.

Merck 

14,6754

InChIKey

SMGTYJPMKXNQFY-UHFFFAOYSA-N

生物活性

Octenidine是一种阳离子型表面活性剂，对革兰氏阳性和阴性的细菌具有活性。

体外研究

Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes a greater than 99% reduction of tested microbial population within 15 min. Staphylococcus epidermidis is the most susceptible of the test organisms, and E. coli and C. albicans are the least susceptible.

体内研究

The antimicrobial activity of octenidine hydrochloride (OCT) is maintained when applied to the skin of the hands and feet of cynomolgus monkeys. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%. A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine.