氟-氨碇

中文名称:

氟-氨碇

中文同义词:

氟-氨碇;腺嘌呤黄素二核苷酸;二核苷酸核黄素腺苷;二核苷酸黄素腺嘌呤;核黄素腺苷双核苷酸;黄素腺嘌呤二核苷酸;腺嘌呤黄素;腺[嘌呤]黃素二苷酸

英文名称:

FLAVIN ADENINE DINUCLEOTIDE

英文同义词:

adenine-flavindinucleotide;adenine-flavinedinucleotide;adenine-riboflavindinuceotide;flavitan;isoalloxazine-adeninedinucleotide;riboflavin5’-(trihydrogendiphosphate),5’.fwdarw.5’-esterwithadenosine;riboflavin5’-(trihydrogendiphosphate),5’-5’-esterwithadenosine;riboflavin-adeninedinucleotide

CAS号:

146-14-5

分子式:

C27H33N9O15P2

分子量:

785.55

EINECS号:

205-663-1

相关类别:

多核苷酸类;核酸类;生物化学品;化工原料;合成材料中间体;Biochemistry;Vitamin Derivatives;Vitamins;Substrates;Aromatics;Bases Related Reagents;Heterocycles;Isotope Labelled Compounds;Nucleotides;Phosphorylating and Phosphitylating Agents

Mol文件:

146-14-5.mol

密度

2.08±0.1 g/cm3(Predicted)

储存条件

−20°C

形态

powder

酸度系数(pKa)

1.13±0.50(Predicted)

颜色

orange

Merck

4091

稳定性

Stable. Incompatible with strong oxidizing agents.

CAS 数据库

146-14-5

EPA化学物质信息

Riboflavin 5-(trihydrogen diphosphate), P.fwdarw.5-ester with adenosine (146-14-5)

生物活性

Flavin adenine dinucleotide (FAD) 是一种氧化还原辅因子，蛋白质的辅基，在代谢过程中参与了几个重要的酶反应。

靶点

Human Endogenous Metabolite

体外研究

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.

体内研究

Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.

化学性质

橙黄色粉末，有吸湿性，易溶于水，不溶于乙醇，水溶液呈黄绿色荧光，遇碱分解为核黄素。

用途

适用于皮肤黏膜疾患、神经性耳鸣、脑动脉硬化、顽固性头痛、肝硬化、黄疸及其他肝病、眼疾、视网膜疾患。静注过快可见暂性胸部不适。

安全说明

24/25

WGK Germany

RTECS号

AU7470000

8-10-21

海关编码

29349990