沙加霉素
中文名称:
沙加霉素
中文同义词:
小诺米星;硫酸小诺霉素/硫酸小诺米星/硫酸沙加霉素;小诺霉素(标准品);硫酸沙加霉素;硫酸相模霉素;硫酸小诺米星/硫酸沙加霉素;硫酸小诺霉素;硫酸小诺米星
英文名称:
MICRONOMICIN SULFATE
英文同义词:
6-N-METHYLGENTAMICIN C1A HEMIPENTASULFATE;MICRONOMICIN SULFATE;MICRONOMYCIN SULFATE;Micronomicin sulfate JAS1998;D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-a-D-erythro-hexopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-2-deoxy-, sulfate (salt) (9CI);streptamine,o-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-d-erythro-hexop;sulfate,d-1-6))-2-deoxy;yranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(
CAS号:
66803-19-8
分子式:
C20H43N5O11S
分子量:
561.65
EINECS号:
1308068-626-2
相关类别:
抗生素;医药原料药;医药、农药及染料中间体
Mol文件:
66803-19-8.mol
沸点
667℃
RTECS号
WK2196000
闪点
>110°(230°F)
水溶解性
Freely soluble in water
生物活性
Micronomicin sulfate (Gentamicin C2b sulfate) 是从 Micromonospora 中分离出来的氨基糖苷抗生素 (antibiotic)。Micronomicin sulfate 是一种接近庆大霉素类抗生素的广谱抗生素，对假单胞菌、变形杆菌、肺炎克雷伯菌、沙雷菌等具有高的抑制活性 (MIC=0.001-8.3 μg/ml)。
靶点
MIC: 0.001-8.3 μg/ml ( Pseudomonas , Proteus , Klebsiella pneumoniae , Serratia )
体外研究
Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml).
体内研究
Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD 50 in mice of 93 mg/kg.Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over.
Animal Model: Wistar rats
Dosage: 4, 10, 25, 63 mg/kg and 100 mg/kg
Administration: Intravenous injection; 30 days
Result: Led to death of rat at 100 mg/kg.
Animal Model:
Wistar rats
Dosage:
4, 10, 25, 63 mg/kg and 100 mg/kg
Administration:
Intravenous injection; 30 days
Result:
Led to death of rat at 100 mg/kg.
用途
属抗生素类药
用途
用于革兰阴性杆菌所致的各种感染，如菌血症、呼吸系统、胆管、尿路感染等。局部滴眼治疗敏感菌引起的眼睑炎、泪囊炎、结膜炎、角膜炎等。
