中文名称:

来普霉素B

中文同义词:

来普霉素B 1%溶液;LEPTOMYCIN B (0.2MG/ML) 来普霉素B(出核转运抑制剂 0.2MG/ML);来普霉素B(出核转运抑制剂 0.2MG/ML);细霉素B;来普霉素B;来普霉素;LEPTOMYCIN B 来普霉素B(出核转运抑制剂 0.2MG/ML);LEPTOMYCIN B (5 ΜG/ML IN ETHANOL)

英文名称:

LEPTOMYCIN B FROM STREPTOMYCES SP

英文同义词:

Leptomycin B (CI 940;InSolution Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem;(2E,10Z,12E,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxo-nonadeca-2,10,12,16,18-pentaenoic acid;2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-;2,10,12,16,18-Nonadecapentanoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid;LeptoMycin B( CI 940, LMB);antibioticcl1957a

CAS号:

87081-35-4

分子式:

C33H48O6

分子量:

540.73

EINECS号:

617-954-4

相关类别:

微生物代谢物;抗生素;生化试剂;其他生化试剂;医药原料;antibiotic;Antifungal

Mol文件:

87081-35-4.mol

熔点 

41-44°, with prior softening (Hokanson)

比旋光度 

D -24.5° (c = 0.70 in MeOH); D23 -157 ° (c = 0.7% in chloroform)

闪点 

11°(52°F)

储存条件 

−20°C

形态

Liquid

生物活性

Leptomycin B (CI 940; LMB) 是一种蛋白出核转运抑制剂。Leptomycin 通过半胱氨酸残基处的共价修饰使 CRM1/exportin 1 失活。 Leptomycin B 是一种有效的抗真菌抗生素，可阻断真核细胞周期。

靶点

CRM1/exportin 1

危险品标志 

F,T

危险类别码 

23/25-36/38-39/23/24/25-23/24/25-11

安全说明 

7-16-24-33-45-36/37

危险品运输编号 

UN 1230 3/PG 2

WGK Germany 

3

HazardClass 

3

海关编码 

29419090