中文名称:

羟基香豆素

中文同义词:

羟基香豆素;(±)-5-乙基-5-(4-羟苯基)-3-甲基海因;(±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮;(+/-)-4-羟基美芬妥英;4羟基美芬妥英;3-甲基-5-乙基-5-(4-羟基苯基)-2,4-咪唑烷二酮;美芬妥英杂质1;(+/-)-4-HYDROXY MEPHENYTOIN

英文名称:

4-HYDROXY MEPHENYTOIN

英文同义词:

(+/-) -HYDROXYMEPHENYTOIN;5-Ethyl-5-(4-hydroxyphenyl)-3-Methyl-;(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione;4-Hydroxy-5-ethyl-3-methyl-5-phenylimidazolidin-2-one;4-Hydroxymephenitoyn;5-(p-Hydroxyphenyl)-3-methyl-5-ethyl-imidazolidine-2,4-dione;5-Ethyl-3-methyl-5-(4-hydroxyphenyl)hydantoin;5-Ethyl-3-methyl-5-(4-hydroxyphenyl)imidazolidine-2,4-dione

CAS号:

61837-65-8

分子式:

C12H14N2O3

分子量:

234.25

EINECS号:

相关类别:

体外研究产品-体外代谢标准品;Chemical Synthesis;Heterocyclic Building Blocks;Imidazolines/Imidazolidines;Metabolites;Building Blocks;Heterocycles;Hydantoins Derivatives;Intermediates Fine Chemicals;Metabolites Impurities;Pharmaceuticals

Mol文件:

61837-65-8.mol

熔点 

153-154 °C

密度 

1.249±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

DMSO: >5mg/mL

酸度系数(pKa)

8.31±0.70(Predicted)

颜色

white

生物活性

4-Hydroxymephenytoin 是抗癫痫药 mephenytoin 的代谢物; mephenytoin 为 CYP2C19 的一种配体。

体外研究

4-Hydroxymephenytoin is a metabolism of mephenytoin, which is an antiepileptic drug, and used as a CYP2C19 substrate. 4-Hydroxymephenytoin (4-Hydroxymephenytoin) is used for developing UltraPerformance LC (UPLC) tandem mass spectrometry assays for evaluating CYP probe drugs and their relevant metabolites in human urine or plasma samples.

WGK Germany 

3