中文名称:

乙苄香豆

中文同义词:

乙苄香豆;苯丙香豆素;4-羟基-3-(1-苯基丙基)-2H-苯并吡喃-2-酮;苯丙香豆素(乙苄香豆);苯丙羟基香豆素

英文名称:

PHENPROCOUMON

英文同义词:

PHENPROCOUMON;2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-phenylpropyl)-;3-(1-Phenylpropyl)-4-hydroxycoumarin;3-(1-Phenyl-propyl)-4-oxycoumarin;3-(alpha-Ethylbenzyl)-4-hydroxycoumarin;4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one;4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one;Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy-

CAS号:

435-97-2

分子式:

C18H16O3

分子量:

280.32

EINECS号:

207-108-9

相关类别:

化工原料

Mol文件:

435-97-2.mol

熔点 

179-180°

沸点 

463.2±45.0 °C(Predicted)

密度 

1.261±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

4.50±1.00(Predicted)

EPA化学物质信息

Phenprocoumon (435-97-2)

生物活性

Phenprocoumon (Marcoumar, Marcumar and Falithrom) 是一种维生素K还原酶， IC50为1 μM。

靶点

Vitamin K.

体内研究

After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [ 3 H]vitamin K 1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [ 3 H]vitamin K 1 concentration in the liver decreases and the [ 3 H] vitamin K 1 -2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats.

危险品运输编号 

2811

HazardClass 

6.1(b)

PackingGroup 

III