中文名称:

AC-ASP-GLU-VAL-ASP-7-氨基-4-三氟甲基香豆素

中文同义词:

AC-ASP-GLU-VAL-ASP-7-氨基-4-三氟甲基香豆素;CASPASE 3/7荧光底物AC-DEVD-AFC 绿;胱天蛋白酶CASPASE 3/7荧光底物AC-DEVD-AFC 绿

英文名称:

AC-DEVD-AFC

英文同义词:

N-ACETYL-ASP-GLU-VAL-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;N-ACETYL-ASP-GLU-VAL-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN);N-ACETYL-ASP-GLU-VAL-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC;CASPASE 3 (APOPAIN) SUBSTRATE 1F, FLUOROGENIC;CASPASE-3 SUBSTRATE (AFC);CASPASE-3 SUBSTRATE VII, FLUOROGENIC;CASPASE-3 FLUOROGENIC SUBSTRATE;FLUOROGENIC CASPASE 3 SUBSTRATE AC-DEVD-AFC

CAS号:

201608-14-2

分子式:

C30H34F3N5O13

分子量:

729.61

EINECS号:

相关类别:

多肽;酶底物;Pepetides;peptide;Caspases/Apoptosis

Mol文件:

201608-14-2.mol

沸点 

1152.7±65.0 °C(Predicted)

密度 

1.495±0.06 g/cm3(Predicted)

储存条件 

-20°C

溶解度 

H2O: 1 mg/mL

形态

powder

酸度系数(pKa)

4.09±0.10(Predicted)

颜色

white

生物活性

Ac-DEVD-AFC 是一种荧光底物 (λex=400 nm, λem=530 nm)。

体外研究

After incubation with Ac-DEVD-AFC for 1 hour, significant increase of caspase-3 activity is observed at 4 hour compare with control. There are no significant increases of caspase-3 activity in Photofrin and LPLI group. The cleavage of Ac-DEVD-AFC in response to caspase-3 activation is remarkably inhibited by shRNA-BimL transfection.

WGK Germany 

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