B-赤霉醇
中文名称:
B-赤霉醇
中文同义词:
B-赤霉醇;-ZEARALANOL;Β-玉米赤霉醇;BETA-玉米赤霉醇
英文名称:
BETA-ZEARALANOL
英文同义词:
taleranol;BETA-ZEARALANOL;2,4-DIHYDROXY-6-[6BETA,10-DIHYDROXY-UNDECYL)BENZOIC ACID MICRO-LACTONE;Taleranol (β-Zearalanol);B-zearalanol;BETAZERANOL;(3S,7S)-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one;(4S)-4β-Methyl-8β,16,18-trihydroxy-3-oxabicyclo[12.4.0]octadecane-1(14),15,17-triene-2-one
CAS号:
42422-68-4
分子式:
C18H26O5
分子量:
322.4
EINECS号:
636-982-8
相关类别:
微生物代谢物;霉菌毒素类;医药原料;Heterpocycles;Aromatics;Chiral Reagents;Intermediates Fine Chemicals;Pharmaceuticals
Mol文件:
42422-68-4.mol
熔点
134-137°C
闪点
2℃
储存条件
2-8°C
BRN
4844761
生物活性
Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素，可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以与葡萄糖醛酸 (glucuronic acid) 结合。
体外研究
βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC 50 of 25 μM. βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC 50 of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC 50 values of 19.8 uM, 16.8 uM, respectively. βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol.
Cell Viability Assay
Cell Line: HepG2 cells
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.
Cell Proliferation Assay
Cell Line: BGC cells
Concentration: 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM
Incubation Time: 24 hours
Result: Inhibited cell proliferation in a dose-dependent manner.
RT-PCR
Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Had the higher cytotoxic effect in comparation with α-Zearalenol.
Cell Line:
HepG2 cells
Concentration:
0-100 μM
Incubation Time:
72 hours
Result:
Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.
Cell Line:
BGC cells
Concentration:
0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM
Incubation Time:
24 hours
Result:
Inhibited cell proliferation in a dose-dependent manner.
Cell Line:
HepG2 cells
Concentration:
1 μM, 5 μM, 10 μM
Incubation Time:
72 hours
Result:
Had the higher cytotoxic effect in comparation with α-Zearalenol.
危险品标志
T,Xn,F
危险类别码
60-36/37/38-36-20/21/22-11
安全说明
53-36/37/39-45-36/37-16
危险品运输编号
UN 1648 3 / PGII
WGK Germany
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