中文同义词:
马尿酸乌洛托品;环六亚甲基四胺 N-苯甲酰甘氨酸盐;马尿酸孟德立胺;马尿酸乌洛托 USP标准品
英文名称:
Methenamine hippurate
英文同义词:
1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane, compd. with N-benzoylglycine (1:1);N-benzoylglycine, compound with 1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane (1:1);METHENAMINEHIPPURATE,USP;N-Benzoylglycine 1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane (1:1);Hexamethylentetramine monohippurate;Methenamine hippurate;Methinamine hippurate(USP);glycine,n-benzoyl-,compd.with1,3,5,7-tetraazatricyclo(3.3.1.1(sup3,7))de
相关类别:
其他原料药;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals
储存条件
Inert atmosphere,Room Temperature
用途
马尿酸乌洛托品作为防治尿路感染的抗生素替代药物具有深远意义，它能降低抗生素使用，减少细菌耐药。
生物活性
Methenamine Hippurate是methenamine的马草酸盐形式，是一种前药和惰性弱碱，在酸性尿液中会水解成甲醛。Methenamine Hippurate是Hiprex药物的成分，具有抗菌活性。
体外研究
Methenamine hippurate is a urinary antibacterial agent which releases formaldehyde and is excreted in the urine. Methenamine hippurate has a demonstrable activity in vitro at pH 5 to 6 against Escherichia coli , Staphylococcus aureus , Aerobacter aeroaenes , Pseudomonas aeruginosa and Proteus vulgaris , and a wide range of action against Klebsiella pneumoniae , Ps. aeruginosa , E. coli , Staph. aureus and Streptococcus haemolytic at pH of 7.4. This action is more effective than that of Methenamine alone, of Hippuric acid alone or of Sulphadiazine.
