卡巴多
中文名称:
卡巴多
中文同义词:
N,N’-二氧化甲基(2-喹喔啉基亚甲基)肼羧酸酯;卡巴多司;卡巴多;卡巴氧;2-(喹喔啉-2-亚甲基)肼-羧酸甲酯-N,N-二氧化物;2(2-喹啉基-1,1-亚甲基)肼基甲酸甲酯;喹肼脂;痢立清
英文名称:
Carbadox
英文同义词:
2-formylquinoxaline1,4-dioxidecarbomethoxyhydrazone;3-(2-chinoxalinylmethylen-1,4-dioxid)methylkarbazat;carbazicacid,3-(2-quinoxalinylmethylene)-,methylester,n(sup1),n(sup4)-di;methyl3-(2-quinoxalinylmethylene)carbazate-n1,n4-dioxide;CARBADOX;LABOTEST-BB LT00771878;2-(2-quinoxalinylmethylene)hydrazine-carboxylic acid methyl ester n,n-dioxide;3-[2-QUINOXALINYLMETHYLENE]CARBAZIC ACID METHYL ESTER N,N-DIOXIDE
CAS号:
6804-07-5
分子式:
C11H10N4O4
分子量:
262.22
EINECS号:
229-879-0
相关类别:
分析标准品;其他兽药标准品;小分子抑制剂;生命科学标准品;饲料添加剂;Veterinaries;Intermediates Fine Chemicals;Nitric Oxide Reagents;Pharmaceuticals
Mol文件:
6804-07-5.mol
熔点
239-240°C
沸点
405.47°C (rough estimate)
密度
1.3602 (rough estimate)
折射率
1.6000 (estimate)
闪点
18°(64°F)
储存条件
2-8°C
形态
powder
酸度系数(pKa)
10.51±0.46(Predicted)
水溶解性
Soluble in 1N NaOH (50 mg/ml), and water (partly).
CAS 数据库
6804-07-5
EPA化学物质信息
Hydrazinecarboxylic acid, 2-[(1,4-dioxido-2-quinoxalinyl)methylene]-, methyl ester (6804-07-5)
生物活性
Carbadox 是一种喹喔啉二氧化氮抗生素化合物，广泛用于育龄期的猪，以控制肠道疾病，提高饲料利用率。
靶点
Bacterial
体外研究
The results of MTT assay demonstrate a dose-dependent decrease in mitochondrial activity in Vero cells at all concentrations of Carbadox. Treatment with Carbadox at the highest concentration of 160 μg/mL results in cell viability down to only 12%. Cells following Carbadox treatment show a dose-dependent increase of the DNA migration (p<0.01). The nuclear division index (NDI) reduces markedly with the increase doses of Carbadox.
体内研究
Alpha diversities (Shannon diversity, Heips evenness, and inverse Simpson indices) of samples from medicated piglets compare to non-medicated piglets are significantly different at 2, 3, and 4 days after continuous Carbadox, but not different in either late Carbadox or at any time during the withdrawal period. Analysis of the community structure of bacteria in animals shows significant differences at days 3 and 4 of early Carbadox treatment ([R=0.32, p=0.015] and [R=0.54, p=0.003], respectively), but not before starting antibiotic treatment (p=0.82). No significant differences in E. coli colony forming units (CFUs) are observed during the Carbadox-treatment period of the study or late in the withdrawal period. E. coli CFUs are significantly different between the medicated and non-medicated groups on day 2 after the withdrawal of Carbadox.
用途
用作药用辅料、饲料添加剂
危险品标志
F,T
危险类别码
45-11-22
安全说明
53-45
危险品运输编号
UN 1325 4.1/PG 2
WGK Germany
3
RTECS号
FE2779000
HazardClass
4.1
海关编码
29339900
毒害物质数据
6804-07-5(Hazardous Substances Data)
