中文名称:

芍药甙元酮

中文同义词:

芍药甙元酮;芍药苷元酮

英文名称:

paeoniflorigenone

英文同义词:

paeoniflorigenone;2,5-Methano-1,3-benzodioxol-6(3aH)-one, 8-[(benzoyloxy)methyl]tetrahydro-3a-hydroxy-7a-methyl-, (2S,3aR,5R,7aS,8S)-

CAS号:

80454-42-8

分子式:

C17H18O6

分子量:

318.32

EINECS号:

相关类别:

标准品;植物提取物;中药对照品;对照品;其它萜类;标准品，对照品

Mol文件:

80454-42-8.mol

沸点 

481.1±45.0 °C(Predicted)

密度 

1.396±0.06 g/cm3(Predicted)

酸度系数(pKa)

11.81±0.60(Predicted)

CAS 数据库

80454-42-8

生物活性

Paeoniflorigenone 是从牡丹皮中提取的一种有效成分，具有选择性诱导肿瘤细胞凋亡 (apoptosis) 和抗增殖作用。

体外研究

Paeoniflorigenone (0-30 μM; 0-72 hours) significantly decreases the cell proliferation of tumor cell lines and inhibits the proliferation of normal cell lines. Paeoniflorigenone (0-30 μM; 24-72 hours) significantly induces apoptotic DNA fragmentation selectively in tumor cells. Cell Proliferation Assay Cell Line: TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells Concentration: 0-30 μM Incubation Time: 0-72 hours Result: Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines. Apoptosis Analysis Cell Line: TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells) Concentration: 0, 1, 3, 10, 30 μM Incubation Time: 24 and 72 hours Result: Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines.

Cell Line:

TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells

Concentration:

0-30 μM

Incubation Time:

0-72 hours

Result:

Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines.

Cell Line:

TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells)

Concentration:

0, 1, 3, 10, 30 μM

Incubation Time:

24 and 72 hours

Result:

Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines.