可的松
中文名称:
可的松
中文同义词:
皮质酮/可的松;可的松-D2;甲醇中可的松溶液标准物质;11-去氢-17-羟皮质甾酮;17-羟-11-脱皮质酮;17-羟-11脱氢皮质酮;可的松;肾上腺皮质激素
英文名称:
CORTISONE
英文同义词:
17,21-Dihydroxy-4-pregnene-3,11,20-trione;17,21-Dihydroxypregn-4-ene-3,11,20-trione;20-trione,17,21-dihydroxy-pregn-4-ene-11;Adrenalex;Adreson;Andreson;Corlin;Cortadren
CAS号:
53-06-5
分子式:
C21H28O5
分子量:
360.44
EINECS号:
200-162-4
相关类别:
甾体激素 (激素，糖皮激素);甾体激素类;医药原料药;脂类;小分子抑制剂;小分子抑制剂，天然产物;激素;生化试剂;生物化学品;Steroids;Biochemistry;Hydroxyketosteroids;Intermediates Fine Chemicals;Pharmaceuticals;Intracellular receptor;Inhibitors;对照品;标准品 -中药标准品;医药原料
Mol文件:
53-06-5.mol
熔点
223-228 °C (dec.)(lit.)
比旋光度
D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
沸点
412.46°C (rough estimate)
密度
1.28±0.1 g/cm3 (20 ºC 760 Torr)
折射率
210 ° (C=1, EtOH)
闪点
9℃
储存条件
-20°C Freezer
酸度系数(pKa)
12.37±0.60(Predicted)
水溶解性
229.9mg/L(25 ºC)
Merck
2539
CAS 数据库
53-06-5(CAS DataBase Reference)
生物活性
Cortisone是一种孕烷甾类激素，是身体应对压力应激时释放的主要物质。它能抑制免疫系统，从而减少炎症反应和炎性疼痛、伤处肿胀。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).
体内研究
Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.
Animal Model: Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion
Dosage: 2 mg/kg
Administration: Intramuscular injection on alternate days for 2 months
Result: Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.
Animal Model:
Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion
Dosage:
2 mg/kg
Administration:
Intramuscular injection on alternate days for 2 months
Result:
Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.
化学性质
白色结晶性粉末。Mp220-224℃(部分分解)，比旋光度[α]25D+209°(1.2%，95%乙醇)、[α]25546+269°(0.125%，苯)。溶于甲醇、乙醇、丙酮；微溶于乙醚、氯仿和苯；难溶于水，水溶液呈中性。在浓硫酸中呈橙红色，并显绿色荧光。
用途
生化研究；皮质激素类药物，具有抗炎、抗过敏等作用。
用途
为肾上腺皮质激素类药，适用于治疗活动性风湿症、类风湿关节炎、过敏性皮炎及过敏恶性循性结膜炎等病
生产方法
以醋酸孕甾双烯醇酮为原料，依次经过氧化氢氧化、沃氏氧化、黑根菌生物氧化、铬酐氧化得11-酮基-16，17α环氧黄体酮，经氢溴酸开环，氢化脱溴得粗品，再重结晶制得。
危险品标志
F,T,Xn
危险类别码
11-23/24/25-39/23/24/25-63
安全说明
22-24/25-45-36/37-16-7
危险品运输编号
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany
3
RTECS号
GM9020000
F
18
海关编码
2937210000
