中文同义词:
人ACTH (1-39)肽;丝拉克肽;六氟硅酸;丝拉克肽, ≥97% (HPLC);促肾上腺皮质激素(1-39)
英文同义词:
CORTICOTROPIN (HUMAN);CORTICOTROPHIN;CORTICOTROPIN A;H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH;ACTH (1-39) (huMan) Corticotropin;Adrenocorticotropic Hormone (ACTH) (1-39);Seractide acetate;Adrenocorticotropic Hormone (ACTH) (1-39), human
相关类别:
原料药;多肽;多肽中间体;细胞生物学;细胞信号和神经生物学;多肽系列;现货;生化试剂-蛋白质;药物多肽;Peptide;Melanocortin receptor
储存条件
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度
H2O: 1 mg/mL, clear, colorless
生物活性
Adrenocorticotropic Hormone (ACTH) (1-39), human 是一种黑皮质素受体 (melanocortin receptor) 激动剂。
体外研究
Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS.
用途
可用于生产促肾上腺皮质激素（ACTH），助应素。在兽药生产上，可用于促黄体激素和促卵泡激素的生产。
