中文同义词:
毛花洋地黄甙丙;毛花甙丙;去乙酰毛花洋地黄甙;毛花苷C;毛花洋地黄苷;毛花甙C(地高辛杂质H);地高辛杂质H(EP);去乙酰基毛花洋地黄甙
英文同义词:
LANATOSIDE C;20(22),5BETA-CARDENOLID-3BETA,12BETA,14BETA-TRIOL 3BETA-O-BETA-D-GLUCOPYRANOSYL-(1->4)-O-BETA-D-[3-O-ACETYLDIGITOXOPYRANOSYL]-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE;Lanatoside C (Digoxin Impurity H);cedilanid;digilanidc;digilanidec;Digoxin EP Impurity H;Digoxin Impurity 8(Digoxin EP Impurity H)
相关类别:
碳水化合物;生化试剂;植物提取物;小分子抑制剂;分析试剂标准品;对照品;中草药成分;标准品 -中药标准品;对照品;Cardioglycosides Glycosides;Carbohydrates;Carbohydrates A to;Carbohydrates H-LBiochemicals and Reagents;Oligosaccharide;Intermediates Fine Chemicals;Oligosaccharides;Pharmaceuticals;Steroids;DIFFERIN
比旋光度
D20 +33.4 to +33.7° (200 mg dry weight in 10 ml alcohol)
沸点
741.7°C (rough estimate)
密度
1.42±0.1 g/cm3 (20 ºC 760 Torr)
酸度系数(pKa)
12.89±0.70(Predicted)
生物活性
Lanatoside C 是具有抗病毒和抗肿瘤活性的强心苷。Lanatoside C 通过减弱 MAPK，Wnt，JAK-STAT和PI3K/AKT/mTOR信号通路，诱导G2/M细胞周期停滞并诱导自噬和细胞凋亡。
体外研究
Dose-dependent reduction in dengue viral RNA and viral proteins synthesis were also observed upon treatment with increasing concentrations of Lanatoside C. Time of addition study indicated that Lanatoside C inhibits the early processes of the dengue virus replication cycle. Furthermore, Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71. Lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses.
