地诺前列素氨丁三醇
中文名称:
地诺前列素氨丁三醇
中文同义词:
缓血酸胺盐;前列腺素 F2ΑTRIS 盐;地诺前列素氨丁三醇38562-01-5,工厂零售38562-01-5;地诺前列素氨丁三醇;氨丁三醇地诺前列素;地诺前列素氮三丁醇;地诺前列腺素 氨丁三醇;地诺前列素氨丁三醇 EP标准品
英文名称:
Prostaglandin F2a tris salt
英文同义词:
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,11α,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Prostaglandin F2α THAM salt;Prostaglandin F2α tris(hydroxymethyl)aminomethane;Prostaglandin F2α tris(hydroxymethyl)aminomethane salt;Prostaglandin F2α tromethamine;Prostaglandin F2α tromethamine salt;Prostaglandin F2α-tham;THAM PGF2α
CAS号:
38562-01-5
分子式:
C24H45NO8
分子量:
475.62
EINECS号:
254-002-3
相关类别:
医药原料药;合成;原料药;前列素类;化工原料;APIs
Mol文件:
38562-01-5.mol
熔点
100-101°
储存条件
-20°C
溶解度
H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
形态
powder
颜色
white
Merck
13,7970
BRN
4087514
InChIKey
IYGXEHDCSOYNKY-RZHHZEQLSA-N
生物活性
Dinoprost Tromethamine (Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol) 是一种合成的prostaglandin F2 alpha类似物，prostaglandin F2 alpha可通过直接作用于黄体素，刺激子宫肌层活性、使宫颈舒张、抑制黄体类固醇生成、诱导黄体溶解。
靶点
FP Receptor
Human Endogenous Metabolite
FP Receptor
Human Endogenous Metabolite
体外研究
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.
Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.
Apoptosis Analysis
Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: Significantly increased the apoptotic rate (15.62±3.12%).
Cell Autophagy Assay
Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.
Western Blot Analysis
Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
Cell Line:
Goat luteal cells
Concentration:
1 μM
Incubation Time:
For 24 hours
Result:
Significantly increased the apoptotic rate (15.62±3.12%).
Cell Line:
Goat luteal cells
Concentration:
1 μM
Incubation Time:
For 24 hours
Result:
There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.
Cell Line:
Goat luteal cells
Concentration:
1 μM
Incubation Time:
For 24 hours
Result:
The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
危险品标志
T
危险类别码
60-22
安全说明
53-45
WGK Germany
3
RTECS号
UK8025000
F
8-10
海关编码
2937500000
