异牡荆黄素
中文名称:
异牡荆黄素
中文同义词:
异牡荆黄素, 来源于山楂树;异牡荆素(UNDER DEVELOPMENT);异黄链霉素;异牡荆黄素;4H-1-BENZOPYRAN-4-ONE,6-尾-D-GLUCOPYRANOSYL-5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-
英文名称:
ISOVITEXIN
英文同义词:
APIGENIN-6-C-GLUCOSIDE;HOMOVITEXIN;SAPOMARETOM;SAPONARETIN;Isovitexin, froM Crataegus pinnatifida;ISOVITEXIN; APIGENIN 6-C-Β-D-GLUCOSIDE;6-C-Glucosylapigenin;C01714
CAS号:
38953-85-4
分子式:
C21H20O10
分子量:
432.38
EINECS号:
相关类别:
合成;标准品;高纯试剂;植物提取物;植提标准品;对照品;标准品，对照品;对照品-中药对照品;黄酮;标准品 -中药标准品
Mol文件:
38953-85-4.mol
熔点
257-258 °C
沸点
807.0±65.0 °C(Predicted)
密度
1.686±0.06 g/cm3(Predicted)
储存条件
2-8°C
酸度系数(pKa)
5.93±0.40(Predicted)
形态
neat
BRN
66651
简介
异牡荆黄素是从亚洲水稻种得到的黄酮类物质，具有抗氧化、抗炎的活性；Isovitexin 作用与 JNK1/2 的抑制剂类似，能够抑制 NF-κB 的活化。
生物活性
Isovitexin 是从亚洲水稻种得到的黄酮类物质，具有抗氧化、抗炎的活性；Isovitexin 作用与 JNK1/2 的抑制剂类似，能够抑制 NF-κB 的活化。
靶点
JNK1
JNK2
NF-κB
JNK1
JNK2
体外研究
Isovitexin protects against LPS-induced oxidative damage by suppressing intracellular ROS generation, and also attenuates the effect of H 2 O 2 on cell viability. Isovitexin (0-100 μg/mL) with LPS (2 μg/mL) is not cytotoxic to RAW 264.7 cells, but 200 μg/mL Isovitexin shows significant cytotoxicity. Isovitexin (25, 50 μg/mL) inhibits LPS-induced increases in TNF-α, IL-6, iNOS, and COX-2 levels. Isovitexin (25, 50 μg/mL) also suppresses the IκBα phosphorylation and degradation in RAW 264.7 cells, and such an effect is consistent with that of JNK1/2 inhibitor.
体内研究
Isovitexin (50 and 100 mg/kg, i.p.) causes less severe histopathological changes in the lung sections, and reduces inflammatory cell count in LPS-induced mice. Isovitexin (50 and 100 mg/kg, i.p.) protects against LPS-induced inflammation and oxidative stress in LPS-induced ALI mice by decreasing TNF-α and IL-6 production, ROS generation, and MPO and MDA content, increasing SOD and GSH levels and effectively inhibiting the protein expression of iNOS and COX-2. Isovitexin (25, 50, 100 mg/kg) dose-dependently reduces the survival rate of LPS/D-gal induced hepatic injury in mice. Isovitexin also inhibits NF-κB activation and up-regulates Nrf2 and HO-1 induced by LPS/D-gal in mice.
化学性质
淡黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于山楂叶，竹叶，新西兰牡荆 Vitex lucens，滨牡荆 Virex littoralis，皂荚 Gleditsia sinensis [Syn．Gleditsia horrida]，酸角 Tamarindus indica，亚麻 Linum usitatissimum，獐牙菜 Swertia pseudochinensis．。
用途
异牡荆素具有抗炎、抗氧化、抗肿瘤、降血压的作用。
WGK Germany
3
海关编码
29329990
