中文名称:

梓醇 6-咖啡酸酯

中文同义词:

梓醇 6-咖啡酸酯

英文名称:

[(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside

英文同义词:

[(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside;Verminoside;Vermiside;Caffeoyl catalpol;Catalpol 6-caffeate;β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-6-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl

CAS号:

50932-19-9

分子式:

C24H28O13

分子量:

524.48

EINECS号:

相关类别:

环烯醚萜;标准品 -中药标准品

Mol文件:

50932-19-9.mol

沸点 

820.3±65.0 °C(Predicted)

密度 

1.69±0.1 g/cm3(Predicted)

酸度系数(pKa)

9.31±0.10(Predicted)

CAS 数据库

50932-19-9

生物活性

Verminoside 是从 Kigelia africana 分离出的一种环烯醚萜，具有抗炎和显着的抗氧化活性，其自由基清除活性为 2.5 μg/mL。Verminoside 对人淋巴细胞的遗传毒性与 PARP-1 和 p53 蛋白水平升高有关。

靶点

PARP-1

PARP-1

体外研究

Verminoside (Compound 1; 0.01-1 mM; 25 hours; J774.A1 macrophages) treatment shows significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages. Western Blot Analysis Cell Line: J774.A1 macrophages Concentration: 0.01 mM, 0.1 mM or 1 mM Incubation Time: 25 hours Result: Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.

Cell Line:

J774.A1 macrophages

Concentration:

0.01 mM, 0.1 mM or 1 mM

Incubation Time:

25 hours

Result:

Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.