中文名称:

盐酸甲哌卡因

中文同义词:

N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺盐酸盐;盐酸甲哌卡因;盐酸卡波卡因;盐酸甲哌卡因?, BR;甲哌卡因杂质B;盐酸甲哌卡因, 局部麻醉, 电压门控NA+通道阻滞剂;甲哌卡因盐酸盐;盐酸甲哌卡因(碱基)

英文名称:

Mepivacaine hydrochloride

英文同义词:

Mepivacaine Hydrochloride (200 mg);Ropivacaine base Mepivacaine HCL;(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride;1-methyl-2’,6’-pipecoloxylididehydrochloride;Mepivacaine HCl USP;2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride;2,6-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI);2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI)

CAS号:

1722-62-9

分子式:

C15H22N2O.ClH

分子量:

282.81

EINECS号:

217-023-9

相关类别:

医药原料;局部麻醉系列;麻醉类;小分子抑制剂;原料药;对照品-杂质对照品;麻醉药及其辅助药物;药物杂质及中间体;医药原料药;Sodium channel;Amines;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;Analgesic series;API

Mol文件:

1722-62-9.mol

熔点 

255-257°C (dec.)

储存条件 

2-8°C

溶解度 

H2O: soluble20mg/mL, clear

形态

powder

颜色

white to beige

CAS 数据库

1722-62-9(CAS DataBase Reference)

EPA化学物质信息

2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (1722-62-9)

生物活性

Mepivacaine 是一种叔胺，用作局部麻醉剂。

体外研究

Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

体内研究

对马的测试表明，与根据以前解剖的，乳胶注射后得到的假定相比，mepivacaine在相邻关节结构间具有更大的扩撒，与关节造影研究形成对比。经历膝关节镜检查患者中，与神经刺激相比较，超声处理使1.5% mepivacaine阻断坐骨神经所需的最低有效麻醉剂体积(MEAV50)减少37%。在犬齿和前臼齿中，lidocaine制剂与肾上腺素相比，3%mepivacaine的使用使麻醉时间间隔更短。

类别

有毒物质

毒性分级

中毒

急性毒性

腹腔-小鼠 LD50: 117 毫克/公斤; 静脉-小鼠 LD50: 35 毫克/公斤

可燃性危险特性

热分解排出有毒氮氧化物烟雾

储运特性

库房低温通风干燥

灭火剂

水, 二氧化碳, 泡沫, 干粉

危险品标志 

Xn

危险类别码 

22

安全说明 

22-24/25

危险品运输编号 

UN 2811 6.1 / PGIII

RTECS号

TK6475000

海关编码 

29333990

毒性

LD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg)