中文名称:

3,17-二丙酸-17-BETA-雌二酯

中文同义词:

3,17-二丙酸-17-BETA-雌二酯;雌二醇二丙酸酯;3.17二丙酸17Β雌二酯;二丙酸雌二醇;雌二醇 3,17-二丙酸酯;1,3,5(10)-雌甾三烯 3,17Β-二丙酸酯;3,17Β-二羟基-1,3,5(10)-雌三烯 3,17-二丙酸酯;Β-雌二醇 3,17-二丙酸酯

英文名称:

17-BETA-ESTRADIOL 3,17-DIPROPIONATE

英文同义词:

(17beta)-Estra-1,3,5(10)-triene-3,17-diol 3,17-dipropionate;(17β)-estra-1,3,5(10)-triene-3,17-dioldipropionate;Ovahormon depot;Ovocyclin dipropionate;ovocyclindipropionate;Ovocyclin-P;Progynon-dp;3,17BETA-DIHYDROXY-1,3,5(10)-ESTRATRIENE 3,17-DIPROPIONATE

CAS号:

113-38-2

分子式:

C24H32O4

分子量:

384.51

EINECS号:

204-026-5

相关类别:

小分子抑制剂;药物杂质及中间体;原料药;Steroids

Mol文件:

113-38-2.mol

熔点 

104-106℃ (ethanol )

沸点 

431.17°C (rough estimate)

密度 

1.0474 (rough estimate)

折射率 

1.4860 (estimate)

Merck 

13,3738

生物活性

Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate)是一种半合成的甾体雌激素，用于女性更年期症状和低雌激素水平的激素治疗，也用于治疗妇科疾病。

体内研究

Treatment of Estradiol dipropionate (2μg per 100 g; single subcutaneous injection) and Chorionic gonadotropin (10 IU per 100 g; sc; twice a day) for 2 days, levels of β-catenin and GSK-3β in luminal and glandular epithelia are lower in Ovariectomized mice. Treatment of Estradiol dipropionate (2 μg per 100 g; once a week) and Chorionic gonadotropin ((10 IU per 100 g; once a day) for a month, the incidence of atypical endometrial hyperplasia is significantly higher, the level of β-catenin is slightly higher, and the expression of GSK-3β is lower in luminal and glandular epithelia.

危险品标志 

Xn

危险类别码 

40-48

安全说明 

22-24/25

RTECS号

KG4725000

毒性

LD50 subcutaneous in rat: > 10gm/kg