阿莫地喹盐酸盐

中文名称:

阿莫地喹盐酸盐

中文同义词:

盐酸阿莫地喹(二水);氨酚喹二盐酸盐二水合物;阿莫地喹二盐酸盐二水合物;4-(7-氯-4-喹啉氨基)-2-([二乙胺基]甲基)苯酚;阿莫地奎盐酸盐;4-(7-氯-4-喹啉基氨基)-2-(二乙基氨基甲基)苯酚二盐酸盐二水合物,98%;AMODIAQUINE二盐酸盐二水合物;阿莫地喹盐酸盐水合物

英文名称:

Amodiaquin dihydrochloride dihydrate

英文同义词:

Amodiaquine hydrochloride USP24;AMODIAQUINE 2HCL DIHYDRATE;AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE;AMODIAQUIN DIHYDROCHLORIDE;amodiaquin dihydrochloride dihydrate;AMODIAQUINE DIHYDROCHLORIDE;AMODIAQUINE HCL;AMODIAQUIN HYDROCHLORIDE

CAS号:

6398-98-7

分子式:

C20H24Cl3N3O

分子量:

428.78

EINECS号:

642-210-0

相关类别:

医药原料;合成;小分子抑制剂;医药原料药-科研原料;医药原料;原料药;医用原料;医用原料;医药原料药;CAMOQUIN;医药、农药及染料中间体;化工原料

Mol文件:

6398-98-7.mol

RTECS号

GO7300100

储存条件

Inert atmosphere,Room Temperature

溶解度

Soluble in DMSO or methanol

形态

neat

最大波长(λmax)

342nm(MeOH)(lit.)

Merck

14,572

CAS 数据库

6398-98-7(CAS DataBase Reference)

生物活性

Amodiaquine在人红细胞中是一种有效的、非竞争性的组胺N-甲基转移酶抑制剂，其Ki值为18.6 nM。它也被用作抗疟疾药和消炎药。

靶点

Target Value histamine N-methyl transferase (Cell-free assay) 18.6 nM(Ki)

Target

Value

histamine N-methyl transferase (Cell-free assay)

18.6 nM(Ki)

体外研究

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner. Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH + neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. RT-PCR Cell Line: Primary microglia Concentration: 10 µM, 15 µM, 20 µM Incubation Time: 4 hours Result: Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.

Cell Line:

Primary microglia

Concentration:

10 µM, 15 µM, 20 µM

Incubation Time:

4 hours

Result:

Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.

体内研究

在狗的体内实验中，小剂量的amodiaquine显著地增强了组胺对胃液分泌的作用。对 P. acnes-primed和LPS诱导的肝炎小鼠中，处理以amodiaquine，能有效阻止严重肝损伤和高致死性，增强了组胺的升高而不升高tele-methylhistamine (t-MeHA)。

用途

用作抗疟药