中文名称:

盐酸比哌立登

中文同义词:

1,3-双(2-乙酰-3-羟基苯氧基)-2-丙醇;盐酸比哌立登;抗胆碱能药物;BIPERIDEN 盐酸盐;盐酸比哌立登( 1,3-双(2-乙酰-3-羟基苯氧基)-2-丙醇);双环哌丙醇盐酸盐;1-(5-双环[2.2.1]庚-2-烯基)-1-苯基-3-(1-哌啶基)丙-1-醇盐酸盐;盐酸比哌立登BIPERIDEN HYDROCHLORIDE

英文名称:

Biperiden hydrochloride

英文同义词:

1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride;NSC 170950;NSC 84989;α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidinepropanol hydrochloride;1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride;1-bicycloheptenyl-1-phenyl-3-piperidinopropanol-1hydrochloride;Akineton, Akinophyl, 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride;1-(Bicyclo[2.2.1]hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol hydrochloride

CAS号:

1235-82-1

分子式:

C21H30ClNO

分子量:

347.92

EINECS号:

214-976-2

相关类别:

信号转导通路激酶抑制剂;小分子抑制剂，天然产物;优势产品;Amines;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Akineton;Inhibitors

Mol文件:

1235-82-1.mol

熔点 

238°

储存条件 

2-8°C

溶解度 

DMSO: >20mg/mL

形态

powder

颜色

off-white

NIST化学物质信息

Akineton, hydrochloride(1235-82-1)

生物活性

Biperiden Hydrochloride (KL 373 Hydrochloride) 是M1胆碱受体阻断剂，可作用于帕金森症。

用途 

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson鈥瞫 Disease (postencephalitic, idiopat hic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.

类别

有毒物品

毒性分级

中毒

急性毒性

口服-大鼠 LD50: 750 毫克/公斤; 口服-小鼠 LD50: 545 毫克/公斤

可燃性危险特性

可燃; 燃烧产生有毒氮氧化物和氯化氢烟雾

储运特性

通风低温干燥

灭火剂

干粉,泡沫,沙土,二氧化碳, 雾状水

危险品标志 

Xn

危险类别码 

22-R22

WGK Germany 

3

RTECS号

TN3706000

毒性

LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)