中文同义词:
雄茸交酯;14-去氧-11,12-二去氢穿心莲内酯;穿心莲内酯 穿心莲乙素;14-脱氧-11,12- 穿心莲内酯;14-脱氧-11,12-二去氢穿心莲内酯, >98%;14-脱氧11,14-二脱氢穿心莲内酯;14-脱氧-11,12-二去氢穿心莲内酯;12-二去氢穿心莲内酯
英文名称:
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
英文同义词:
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone;ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide;11,12-Didehydro-14-deoxyandrographolide;14-Deoxy-11,14-didehydroandrographolide;AP 10;Deoxy-11,12-Didehydroandrographolide, 14-;3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
相关类别:
分析试剂标准品;中草药成分;标准品;植物提取物;标准品 -对照药材;二萜;化工原料;中药对照品
沸点
519.6±50.0 °C(Predicted)
酸度系数(pKa)
14.80±0.70(Predicted)
生物活性
14-Deoxy-11,12-didehydroandrographolide 是 Andrographolide 的类似物。14-Deoxy-11,12-didehydroandrographolide 抑制 NF-κB 活化。
体外研究
14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity.
体内研究
14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine.
