2-氨基-3-氯-1,4-萘醌
中文名称:
2-氨基-3-氯-1,4-萘醌
中文同义词:
氨氯萘醌;2-氨基-3-氯-1,4-萘醌;灭藻醌;2-氨基-3-氯-1,4-萘醌(萘醌杀);2-氨基-3-氯-1,4-萘醌,灭藻醌;银杏内酯K;甲苯中灭藻醌标准品;甲醇中灭藻醌
英文名称:
2-AMINO-3-CHLORO-1,4-NAPHTHOQUINONE
英文同义词:
ACN;3-Chloro-2-aminonaphthalene-1,4-dione;O6K;2-Amino-3-chloro-1,4-naphthoquinone,95%;ASISCHEM T86788;2-AMino-3-chloronaphthalene-1,4-dione;Ginkgolide K;06k
CAS号:
2797-51-5
分子式:
C10H6ClNO2
分子量:
207.61
EINECS号:
220-529-2
相关类别:
试剂和补充物;卤代物;除草剂;药物杂质及中间体;有机化学
Mol文件:
2797-51-5.mol
熔点
198-200 °C
沸点
310℃
密度
1.49
折射率
1.5790 (estimate)
闪点
141℃
储存条件
Keep in dark place,Inert atmosphere,Room temperature
酸度系数(pKa)
0.70±0.20(Predicted)
形态
Powder
颜色
Orange
CAS 数据库
2797-51-5(CAS DataBase Reference)
EPA化学物质信息
2-Amino-3-chloro-1,4-naphthoquinone (2797-51-5)
生物活性
Quinoclamine 是一种萘醌衍生物，是一种 NF-κB 抑制剂。Quinoclamine 具有抗肿瘤活性。
靶点
NF-κB
体外研究
Quinoclamine causes differentiation of U-937 cells into macrophage-like cells.
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC 50 of 1.7 μM.
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation.
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines.
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis.
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism.
Cell Viability Assay
Cell Line: HepG2 cells
Concentration: 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
Incubation Time: 24 hours
Result: Inhibited NF-κB activities in HepG2 cells.
Western Blot Analysis
Cell Line: HepG2 cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 30 minutes
Result: Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells.
Cell Line:
HepG2 cells
Concentration:
1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
Incubation Time:
24 hours
Result:
Inhibited NF-κB activities in HepG2 cells.
Cell Line:
HepG2 cells
Concentration:
0 μM, 1 μM, 2 μM, 4 μM
Incubation Time:
30 minutes
Result:
Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells.
类别
农药
毒性分级
中毒
急性毒性
口服- 大鼠 LD50: 1360 毫克/ 公斤; 口服- 小鼠 LD50: 1260 毫克/ 公斤
可燃性危险特性
燃烧产生有毒氮氧化物和氯化物气体
储运特性
库房通风低温干燥; 与食品原料分开储运
灭火剂
干粉、泡沫、砂土
危险品标志
T,N
危险类别码
36/37/38-23-22-50/53-36
安全说明
45-37/39-26-61-60
危险品运输编号
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany
3
RTECS号
QL7350000
HazardClass
6.1
海关编码
29223990
毒性
LD50 oral in rat: 1360mg/kg
