中文名称:

补骨脂甲素

中文同义词:

补骨脂甲素(补骨脂二氢黄酮);补骨脂二氢黄酮;补骨脂二氢黄酮(标准品);补骨脂二氢黄酮/补骨脂甲素;BAVACHIN 补骨脂二氢黄酮/补骨脂甲素;补骨脂二氢黄酮/补骨脂甲素标准品;BAVACHIN 补骨脂二氢黄酮/补骨脂甲素 标准品;补骨脂甲素, 分析对照品

英文名称:

BAVACHIN

英文同义词:

BAVACHIN;(S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-;Bavachin from Psoralea coryfolia, >=97% (HPLC)

CAS号:

19879-32-4

分子式:

C20H20O4

分子量:

324.37

EINECS号:

相关类别:

标准品-对照品;分析试剂标准品;中药对照品;标准品;对照品,标准品;有机砌块;植物提取物;对照品;植提标准品;酮;对照品-中药对照品;黄酮;标准品 -中药标准品;分析试剂-标准品;标准品，对照品

Mol文件:

19879-32-4.mol

沸点 

558.3±50.0 °C(Predicted)

密度 

1.244

储存条件 

Inert atmosphere,Store in freezer, under -20°C

酸度系数(pKa)

8.27±0.40(Predicted)

CAS 数据库

19879-32-4

生物活性

Bavachin 是从补骨脂种子中分离到的黄酮类物质，作为植物雌激素激活雌性激素受体 ERα 和 ERβ，EC50 值分别为 320 和 680 nM。

靶点

IC50: 320 nM (ERα), 680 nM (ERβ)

体外研究

Bavachin significantly inhibits melanin synthesis and TYR activity. Bavachin (10 µM) inhibits the expression of TYR and JNK proteins, and the expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2 mRNA in A375 cells. ICI182780 and U0126 cAN significantly reverse the bavachin treatment on the protein expression levels and the mRNA expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2. Bavachin accumulates lipid in a dose dependent manner in ORO staining experiments. Bavachin significantly increases the growth of preadipoctye at 10 µM compared with the control cells in MTT assay. Bavachin also increases BrdU incorporation into newly synthesized DNA during pre-adipocyte proliferation. BrdU incorporation is enhanced by insulin and further enhanced by co-treatment with insulin and bavachin at 2 and 10 µM. Bavachin activates adipogenic factors and increases PPARγ transcriptional activity in differentiated adipocytes. Bavachin enhances insulin-stimulated glucose uptake through GLUT4 translocation via Akt and AMPK pathway. BVN significantly increases both hMAO-A and hMAO-B activities. Bavachin shows ER ligand binding activity in competitive displacement of [ 3 H] E2 from recombinant ER. The estrogenic activity of bavachin is characterized in a transient transfection system using ERα or ERβ and estrogen-responsive luciferase plasmids in CV-1 cells with an EC 50 of 320 nM and 680 nM, respectively. Bavachin increases the mRNA levels of estrogen-responsive genes such as pS2 and PR, and decreases the protein level of ERα by proteasomal pathway.

化学性质 

淡黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于补骨脂PsoraleacorylifoliaLinn.的果实。

用途 

补骨脂甲素具有扩张冠状动脉、增强心肌收缩力、提高心脏功率的作用。

用途 

一种植物雌性激素，能激活erα和erβ(EC50s分别为320和680nm)，刺激成骨细胞增殖和分化，防止大鼠去卵巢后骨质流失。