中文名称:

硝酸异康唑

中文同义词:

硝酸异康唑;氯氨酮杂质A;硝酸邻氯益康唑;1-[2-(2,4-二氯苯基)-2-[(2,6-二氯苯基)甲氧基]乙基]-1H-咪唑单硝酸盐;硝酸异康唑(标准品);硝酸异康唑 25KG;咪康唑EP杂质D;硝酸异康唑 EP标准品

英文名称:

Isoconazole nitrate

英文同义词:

1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrate;1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazolium nitrate;1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI);Adestan G 100;Fazol;Gyno-Travogen;Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]-, mononitrate (8CI);R 15454

CAS号:

24168-96-5

分子式:

C18H15Cl4N3O4

分子量:

479.14

EINECS号:

246-051-4

相关类别:

其他原料;医药原料;原料药;解热镇痛;抗生素;小分子抑制剂，天然产物;Aromatics;Heterocycles;Intermediates Fine Chemicals;Inhibitors;抗菌剂;医药化工类;化工原料;医用原料;原料;其他原料药;医药、农药及染料中间体;原药中间体;Antifungal;Pharmaceuticals

Mol文件:

24168-96-5.mol

熔点 

178-182°C

储存条件 

Sealed in dry,2-8°C

溶解度 

Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).

形态

neat

Merck 

14,5160

CAS 数据库

24168-96-5(CAS DataBase Reference)

概述

硝酸异康唑是一种具有广谱抗真菌作用的咪唑类抗真菌药，对白色念珠菌、表皮癣菌及某些革兰阳性菌均有抑制作用。硝酸异康唑于1979年在法国上市，因其具有疗效显著，毒副作用低等优点，具有广阔的市场前景。

生物活性

Isoconazole nitrate 是一种唑类抗真菌药物。

体外研究

Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure. Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells.

用途 

属广谱抗真菌药

RTECS号

NI4772000