(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
中文名称:
(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
中文同义词:
(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯;亚太因
英文名称:
(3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-(1,3-benzodioxole-5-ylmethyl)tetrahydrofuran-2-one
英文同义词:
(-)-Deoxypodorhizone;(3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-(1,3-benzodioxole-5-ylmethyl)tetrahydrofuran-2-one;(3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-[(1,3-benzodioxole-5-yl)methyl]-4,5-dihydrofuran-2(3H)-one;(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-(1,3-benzodioxole-5-ylmethyl)tetrahydrofuran-2-one;(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-benzodioxol-5-yl)methyl]dihydrofuran-2(3H)-one;Yatein;(+)-Deoxypodorhizon;(3S)-3β-(3,4,5-Trimethoxybenzyl)-4α-[(1,3-benzodioxole-5-yl)methyl]-4,5-dihydrofuran-2(3H)-one
CAS号:
40456-50-6
分子式:
C22H24O7
分子量:
400.42
EINECS号:
相关类别:
木脂素;标准品 -中药标准品
Mol文件:
40456-50-6.mol
沸点
564.9±45.0 °C(Predicted)
密度
1.266±0.06 g/cm3(Predicted)
CAS 数据库
40456-50-6
生物活性
Yatein 是从 A. chilensis 中提取的木质素，具有抗增殖活性。Yatein 能通过中断立早基因的表达，抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。
靶点
HSV-1
体外研究
Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells.
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells.
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization.
Cell Viability Assay
Cell Line: A549 cells, CL1-5 cells
Concentration: 1.25 μM , 2.5 μM , 5 μM
Incubation Time: 24 hours
Result: Induced cell-cycle arrest at G2/M phase in both cell lines.
Cell Viability Assay
Cell Line: A549 cells, CL1-5 cells
Concentration: 5 μM
Incubation Time: 6 hours, 12 hours
Result: Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.
Cell Line:
A549 cells, CL1-5 cells
Concentration:
1.25 μM , 2.5 μM , 5 μM
Incubation Time:
24 hours
Result:
Induced cell-cycle arrest at G2/M phase in both cell lines.
Cell Line:
A549 cells, CL1-5 cells
Concentration:
5 μM
Incubation Time:
6 hours, 12 hours
Result:
Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.
体内研究
Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model.
Animal Model: Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, five times per week, for 42 days
Result: Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.
Animal Model:
Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft
Dosage:
20 mg/kg
Administration:
Intraperitoneal injection, five times per week, for 42 days
Result:
Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.
