中文名称:

ICARISIDE E5

中文同义词:

淫羊藿次甙 E5

英文名称:

3-[4-β-D-Glucopyranosyloxy-5-methoxy-3-[2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl]phenyl]-2-propen-1-ol

英文同义词:

3-[4-β-D-Glucopyranosyloxy-5-methoxy-3-[2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl]phenyl]-2-propen-1-ol;Icariside E5;b-D-Glucopyranoside,2-[(1R)-2-hydroxy-1-[(4-hydroxy-3-methoxyphenyl)methyl]ethyl]-4-[(1E)-3-hydroxy-1-propen-1-yl]-6-methoxyphenyl;β-D-Glucopyranoside, 2-[(1R)-2-hydroxy-1-[(4-hydroxy-3-methoxyphenyl)methyl]ethyl]-4-[(1E)-3-hydroxy-1-propen-1-yl]-6-methoxyphenyl

CAS号:

126176-79-2

分子式:

C26H34O11

分子量:

522.54

EINECS号:

相关类别:

标准品;植物提取物;中药对照品;分析试剂标准品;标准品 -对照药材;木脂素

Mol文件:

126176-79-2.mol

沸点 

807.6±65.0 °C(Predicted)

密度 

1.413±0.06 g/cm3(Predicted)

酸度系数(pKa)

10.09±0.20(Predicted)

生物活性

Icariside E5 是从 Albiziae Cortex 分离得到的木脂素糖苷。Icariside E5 促进 HUVEC 的增殖而无细胞毒性。Icariside E5 具有抗氧化性能。

体外研究

Icariside E5 (5, 10, 20, 40 µM; for 48 h) slightly promotes the proliferation of human umbilical vein endothelial cells (HUVECs). Icariside E5 does not have the pharmacological effect of scavenging ROS. Icariside E neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. It protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal.