苯妥英
中文名称:
苯妥英
中文同义词:
5,5-二苯基海因;5,5-二苯基乙内酰脲;苯妥英;5-二苯基海因;苯妥英标准溶液;5,5-二苯基乙内酰脲(苯妥英);苯妥英 溶液;5,5-二苯基海因 溶液
英文名称:
5,5-Diphenylhydantoin
英文同义词:
4,5-Diphenyl-4-imidazoline-2-one;5,5-Diphenyltetrahydroglyoxalin-4-one;5,5-Diphenylhydantoin-2-13C, 3-15N;PHENYTOIN,USP;Dantinal;Dantoinal;Dantoinal klinos;Dantoinalklinos
CAS号:
57-41-0
分子式:
C15H12N2O2
分子量:
252.27
EINECS号:
200-328-6
相关类别:
芳烃;小分子抑制剂;离子通道;膜转运;医药中间体;对照品;APIs;Aromatics;Heterocycles;API intermediate;有机化工原料;医药原料;药物杂质及中间体;医药原料药;中药对照品;化工原料;陕西林奈主打产品
Mol文件:
57-41-0.mol
熔点
293-295 °C (lit.)
沸点
395.45°C (rough estimate)
密度
1.1562 (rough estimate)
折射率
1.5906 (estimate)
闪点
11 °C
储存条件
2-8°C
溶解度
DMSO: soluble
酸度系数(pKa)
pKa 8.43(H2O,t =25,I=0.025) (Uncertain)
形态
Powder
颜色
White to almost white
水溶解性
<0.01 g/100 mL at 19 ºC
Merck
14,7322
BRN
384532
稳定性
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey
CXOFVDLJLONNDW-UHFFFAOYSA-N
CAS 数据库
57-41-0(CAS DataBase Reference)
(IARC)致癌物分类
2B (Vol. Sup 7, 66) 1996
NIST化学物质信息
5,5-Diphenylhydantoin(57-41-0)
EPA化学物质信息
Phenytoin (57-41-0)
生物活性
Phenytoin (Diphenylhydantoin) 是一种失活的电压门控钠离子通道稳定剂。
靶点
Target Value
Sodium channel
Target
Value
Sodium channel
体外研究
Phenytoin is an antiepileptic drug. It is useful to partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels.
Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials.
When neurons are depolarized and the channels transition into the open and inactivated states, greater binding and block occur. The inhibitory potency is strongly use dependent, so that block accumulates with prolonged or repetitive activation, such as occurs during a seizure discharge. The blocking of sodium channels by phenytoin is of slow onset. The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity. Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control. Phenytoin is a class 1b antiarrhythmic.
体内研究
Phenytoin (5,5-Diphenylhydantoin; 60 mg/kg; daily; 28 days ) reduces tumour growth in six week-old female Rag2 -/- Il2rg -/- mice with MDA-MB-231 cells.
用途
用作抗癫痫药、抗心律失常药
危险品标志
T,Xn,F
危险类别码
45-61-22-63-40-39/23/24/25-23/24/25-11-20/21/22
安全说明
53-45-36/37-16-7
危险品运输编号
2811
WGK Germany
3
RTECS号
MU1050000
自燃温度
550 °C
HazardClass
6.1(b)
PackingGroup
II
海关编码
29332100
毒害物质数据
57-41-0(Hazardous Substances Data)
毒性
LD50 in mice (mg/kg): 92 i.v.; 110 s.c. (Stille, Brunckow)
