中文名称:

OSAJIN

中文同义词:

奥沙京

英文名称:

OSAJIN

英文同义词:

OSAJIN;5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)-4H,8H-benzo[1,2-b:3,4-b]dipyran-4-one;5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one;OSAJIN(RG);5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)-4H,8H-pyrano[2,3-f]chromen-4-one;4H,8H-Benzo[1,2-b:3,4-b]dipyran-4-one,5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-buten-1-yl)-;NSC 21565;CID 95168

CAS号:

482-53-1

分子式:

C25H24O5

分子量:

404.46

EINECS号:

相关类别:

标准品;植物提取物;标准品 -对照药材;黄酮

Mol文件:

482-53-1.mol

熔点 

189° (uncorr), 193° (corr)

沸点 

632.3±55.0 °C(Predicted)

密度 

1.258±0.06 g/cm3(Predicted)

储存条件 

-20°C

酸度系数(pKa)

7.00±0.40(Predicted)

CAS 数据库

482-53-1

生物活性

Osajin是 Maclura pomifera 果实中存在的主要生物活性异黄酮，具有抗肿瘤，抗氧化和抗炎活性。

靶点

Apoptosis

体外研究

Osajin significantly decreases the viability of human NPC cells (TW076, CG1 and TW04 cells) in a dose-dependent manner. Osajin induces apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress. Osajin exhibits growth inhibitory activity on six human cancer cell lines, including kidney, lung, prostate, breast, melanoma and colon cancer cells.

体内研究

Osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemia reperfusion. This is confirmed by an increase in both antioxidant enzyme values and total antioxidant activity. The cardioprotection provided by osajin and pomiferin treatment results from the suppression of oxidative stress and this correlates with improved ventricular function.

危险品标志 

N

危险类别码 

50

安全说明 

61

危险品运输编号 

UN 3077 9 / PGIII

WGK Germany 

3