芥子酸

中文名称:

芥子酸

中文同义词:

咖啡酸反式异构体;芥子酸;3,5-二甲氧基-4-羟基-反式-苯乙烯酸,;3,5-二甲氧基-4-羟基苯丙烯酸;順13-二十二烯酸;順二十二碳-13-烯酸;3,5-二甲氧基-4-羥基桂皮酸;3,5-二甲氧基-4-羟基肉桂酸[ MALDI-TOF/MS基质]

英文名称:

4-Hydroxy-3,5-dimethoxycinnamic acid

英文同义词:

3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxycinnamic acid, Sinapic acid;3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapic acid, Sinapinic acid;3,5-Dimethoxy-4-hydroxycinnamic acid, 98%, predominantly trans isomer;3-(3,5-Dimethoxy-4-hydroxyphenyl)acrylic acid;3-(4-Hydroxy-3,5-dimethoxyphenyl)propenoic acid;3,5-Dimethoxy-4-hydroxybenzeneacrylic acid;Synapoic acid;3-(4-Hydroxy-3,5-diMethoxyphenyl)-2-propenoic Acid

CAS号:

530-59-6

分子式:

C11H12O5

分子量:

224.21

EINECS号:

208-487-3

相关类别:

植物提取物;植物生化提取物;医药中间体;营养学研究;生化试剂;对照品;标准品-对照品;羰基化合物;Allium cepa (Onion);Allium sativum (Garlic);Armoracia rusticana (Horseradish);Berberis sp.;Building Blocks;C11 to C12;Carbonyl Compounds;其他生化试剂;生化试剂-其他化学试剂;对照品;苯丙素;标准品，对照品;中药对照品;Aromatic Cinnamic Acids, Esters and Derivatives;Analytical Chemistry;Mass Spectrometry;Matrix Materials (MALDI-TOF-MS);Carboxylic Acids;Chemical Synthesis;Cichorium intybus (Chicory);Linum usitatissimum (Flax);Nutrition Research;Organic Building Blocks;Phytochemicals by Plant (Food/Spice/Herb);Vaccinium macrocarpon (Cranberry);UltraPure MALDI Matrices;proteinmod

Mol文件:

530-59-6.mol

熔点

~202 °C

沸点

285.61°C (rough estimate)

密度

1.1478 (rough estimate)

折射率

1.4720 (estimate)

储存条件

Keep in dark place,Sealed in dry,Room Temperature

溶解度

H2O: slightly soluble

形态

powder

酸度系数(pKa)

4.53±0.10(Predicted)

颜色

white

水溶解性

insoluble

BRN

2130006

稳定性

Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.

CAS 数据库

530-59-6(CAS DataBase Reference)

NIST化学物质信息

Cinnamic acid, 4-hydroxy-3,5-dimethoxy-(530-59-6)

生物活性

Sinapinic acid (Sinapic acid) 是一种天然的小羟基肉桂酸，属于苯基丙烷类，通常在MALDI质谱中用作基质。Sinapinic acid (Sinapic acid) 作为 HDAC 的抑制剂，IC50为2.27 mM，并且还抑制 ACE-1 活性。

靶点

Target Value HDAC () ACE1 ()

Target

Value

HDAC ()

ACE1 ()

体外研究

Sinapinic acid acts as an inhibitor of HDAC, with an IC 50 of 2.27 mM. Sinapinic acid also inhibits ACE-I activity. Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC 50 s of 0.91 ± 0.02 mM and 1.6 ± 0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells.

体内研究

Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats.

化学性质

白色粉末，溶于三氯甲烷，乙醚，甲醇，来源于菜粕。

用途

用于含量测定/鉴定/药理实验等

危险品标志

危险类别码

36/37/38

安全说明

26-36-37/39

WGK Germany

Hazard Note

Irritant