盐酸胡芦巴碱

中文名称:

盐酸胡芦巴碱

中文同义词:

N-甲基烟酸内盐盐酸盐;盐酸葫芦巴碱;胡卢巴碱盐酸盐;盐酸葫芦巴碱葫芦巴碱盐酸盐、N-甲基烟酸内盐盐酸盐;葫芦巴碱盐酸盐(标准品);胡芦巴碱盐酸盐;盐酸胡芦巴碱;葫芦巴碱盐酸盐

英文名称:

Trigonelline hydrochloride

英文同义词:

1-METHYLPYRIDINIUM-3-CARBOXYLATE HYDROCHLORIDE;N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE;TRIGONELLIN HYDROCHLORIDE;TRIGONELLINE HYDROCHLORIDE;TRIGONELLINE HCL;TIMTEC-BB SBB000182;3-carboxy-1-methylpyridinium chloride;EINECS 228-119-5

CAS号:

6138-41-6

分子式:

C7H8ClNO2

分子量:

173.6

EINECS号:

228-119-5

相关类别:

吡啶;小分子抑制剂;植物提取物;对照品;植提标准品;中药对照品;标准品;Alkaloids;Biochemistry;Pyridine Alkaloids;Pyridinium Compounds;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;小分子抑制剂，天然产物;标准品 -中药标准品;标准品，对照品

Mol文件:

6138-41-6.mol

熔点

~260 °C (dec.)

储存条件

Inert atmosphere,Room Temperature

形态

neat

Merck

14,9694

BRN

3734169

CAS 数据库

6138-41-6(CAS DataBase Reference)

生物活性

Trigonelline chloride 是一种大量存在于咖啡中并且具有潜在抗糖尿病活性的生物碱。Trigonelline chloride 具有抗 HSV-1，抗菌和抗真菌活性。

体外研究

It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .

体内研究

Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.

化学性质

可溶于甲醇、乙醇、DMSO等有机溶剂，来源于葫芦巴。

用途

盐酸葫芦巴碱具有降血糖的作用。

危险品标志

危险类别码

36/37/38

安全说明

22-24/25-36-26

WGK Germany

海关编码

29333990