中文名称:

泮托拉唑钠水合物

中文同义词:

泮托拉唑钠倍半结晶水合物;厂家供应/可提供免费样品泮托拉唑钠水合物;特卖 【厂家供应】纯天然 泮托拉唑钠水合物;泮托拉唑钠水合物|泮托拉唑钠水合物医药级99%;泮托拉唑钠水合物164579-32-2含量99%;泮托拉唑钠水合物164579-32-2|医药级99%;优质|泮托拉唑钠水合物|医药级99%;泮托拉唑钠水合物1

英文名称:

PantoprazoleSodiumSesquihydrate

英文同义词:

Pantoprazole sodium hydrate;1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-, sodium salt, hydrate (2:3);Unii-6871619Q5x;6-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate (2:2:3);SKF-96022 SODIUM HYDRATE;Pantoprazole sodium sesquihydrate CRS;Pantoprazole for system suitability CRS;BY1023 (sodium hydrate)

CAS号:

164579-32-2

分子式:

C16H15F2N3O4S.3/2H2O.Na

分子量:

864.75

EINECS号:

1312995-182-4

相关类别:

医药原料 用于消化性溃疡出血;植物提取物;原料药;其他科研原料药;医药中间体;医药原料;原料

Mol文件:

Mol File

溶解度 

Freely soluble in water and in ethanol (96 per cent), practically insoluble in hexane.

形态

neat

生物活性

Pantoprazole sodium hydrate (BY1023 sodium hydrate) 是一种具有口服活性的，有效质子泵 (proton pump) 抑制剂 (PPI)。Pantoprazole sodium hydrate 是一种取代的苯并咪唑，是一种有效的 H+/K+-ATPase 抑制剂，IC50 为 6.8 μM。Pantoprazo sodium hydrate 可以改善 pH 值稳定性，并具有抗分泌，抗溃疡的作用。Pantoprazo sodium hydrate 联合阿霉素 (Doxorubicin; HY-15142) 可显着增加肿瘤生长延迟。

体外研究

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells. Pantoprazole sodium hydrate can block exosome release. Pantoprazole sodium hydrate inhibits the activity of V-H + -ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium

体内研究

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin. Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats. Animal Model: Mice bearing MCF-7 or A431 xenografts Dosage: 200 mg/kg Administration: IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.) Result: Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin. There is no effect on growth delay alone.

Animal Model:

Mice bearing MCF-7 or A431 xenografts

Dosage:

200 mg/kg

Administration:

IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)

Result:

Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin. There is no effect on growth delay alone.

危险品标志 

Xn

危险类别码 

22

WGK Germany 

nwg

海关编码 

2933399090