盐酸环喷托酯

中文名称:

盐酸环喷托酯

中文同义词:

环戊通;盐酸环喷托酯;盐酸环喷脱脂;盐酸环喷托酯杂质;盐酸环喷托酯/环戊通/盐酸环喷脱脂;盐酸环喷托酯标准品;环喷托酯系统适应性 EP标准品;盐酸环喷托酯 USP标准品

英文名称:

CYCLOPENTOLATE HYDROCHLORIDE

英文同义词:

2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid;alpha-(1-hydroxycyclopentyl)-benzeneaceticaci2-(dimethylamino)ethylest;2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride;2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenyl-ethanoate hydrochloride;Cyclopentolate Hydrochloride (300 mg);2-DIMETHYLAMINOETHYL 1-HYDROXY-ALPHA-PHENYLCYCLOPENTANEACETATE HYDROCHLORIDE;Cyclopentolate HCl USP;Benzeneacetic acid, a-(1-hydroxycyclopentyl)-,2-(diMethylaMino)ethyl ester, hydrochloride (1:1)

CAS号:

5870-29-1

分子式:

C17H26ClNO3

分子量:

327.85

EINECS号:

227-521-8

相关类别:

医药原料药;医药原料;原料药;Amines;Aromatics;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

5870-29-1.mol

熔点

137-141°

储存条件

Inert atmosphere,Room Temperature

溶解度

Very soluble in water, freely soluble in ethanol (96 per cent). It shows polymorphism (5.9).

形态

neat

生物活性

Cyclopentolate是毒蝇碱型乙酰胆碱受体拮抗剂，对M1、M2和M3受体的Ki值分别为1.62, 27.5和2.63 nM。

靶点

Target Value M1 receptor (Cell-free assay) 1.62 nM(Ki) M3 receptor (Cell-free assay) 2.63 nM(Ki) M2 receptor (Cell-free assay) 27.5 nM(Ki)

Target

Value

M1 receptor (Cell-free assay)

1.62 nM(Ki)

M3 receptor (Cell-free assay)

2.63 nM(Ki)

M2 receptor (Cell-free assay)

27.5 nM(Ki)

体内研究

Survival in rats pretreated with cyclopentolate (20 mg/kg) is 90%. Animal Model: Eighty Sprague-Dawley rats (acute, lethal organophosphate pesticide (OP) poisoning model) Dosage: 20 mg/kg (Ophthalmic cyclopentolate) Administration: i.p. Result: Survival in rats pretreated with ophthalmic cyclopentolate (20 mg/kg) is 90%.

Animal Model:

Eighty Sprague-Dawley rats (acute, lethal organophosphate pesticide (OP) poisoning model)

Dosage:

20 mg/kg (Ophthalmic cyclopentolate)

Administration:

i.p.

Result:

Survival in rats pretreated with ophthalmic cyclopentolate (20 mg/kg) is 90%.

WGK Germany

RTECS号

GY2450000

海关编码