非诺特罗
中文名称:
非诺特罗
中文同义词:
非诺特罗氢溴酸盐;非诺特罗;5-[1-羟基-2-[[2-(4-羟基苯基)-1-甲基乙基]氨基]乙基]-1,3-苯二酚
英文名称:
Fenoterol
英文同义词:
1-(p-hydroxyphenyl)-2-((beta-hydroxy-beta-(3’,5’-dihydroxyphenyl))ethyl)amin;1,3-benzenediol,5-(1-hydroxy-2-((2-(4-hydroxyphenyl)-1-methylethyl)amino)eth;3,5-dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)methyl)benzyla;benzylalcohol,3,5-dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)me;lcohol;opropane;1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-[1-(4-hydroxyphenyl)isopropyl]aminoethane;1-(3,5-Dihydroxyphenyl)-2-(p-hydroxy-α-methylphenethylamino)ethanol
CAS号:
13392-18-2
分子式:
C17H21NO4
分子量:
303.35
EINECS号:
相关类别:
瘦肉精类;平喘药物;对照品;API
Mol文件:
13392-18-2.mol
熔点
181-183°C
沸点
566.0±45.0 °C(Predicted)
密度
1.289±0.06 g/cm3(Predicted)
酸度系数(pKa)
pKa 8.5 (Uncertain);10.0 (Uncertain)
CAS 数据库
13392-18-2(CAS DataBase Reference)
生物活性
Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂，具有支气管扩张活性。
靶点
Target Value
β2 adrenoreceptor
()
Target
Value
β2 adrenoreceptor
()
体外研究
Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.
Western Blot Analysis
Cell Line: THP-1 cells stimulated with AICAR
Concentration: 1 μM
Incubation Time: Pre-incubated 30 minutes
Result: Significantly downregulated the elevated phosphorylation levels of AMPK.
Cell Line:
THP-1 cells stimulated with AICAR
Concentration:
1 μM
Incubation Time:
Pre-incubated 30 minutes
Result:
Significantly downregulated the elevated phosphorylation levels of AMPK.
体内研究
Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.
Animal Model: Male C57BL/6J mice (6 weeks old) with neuropathy
Dosage: 0.7 mg/kg
Administration: Intraperitoneal injection; twice a day; for 3 weeks
Result: Alleviated neuropathic allodynia during chronic treatment.
Animal Model:
Male C57BL/6J mice (6 weeks old) with neuropathy
Dosage:
0.7 mg/kg
Administration:
Intraperitoneal injection; twice a day; for 3 weeks
Result:
Alleviated neuropathic allodynia during chronic treatment.
