中文名称:

2-吲哚酮

中文同义词:

2-吲哚酮;氧化吲哚;羟吲哚;2-吲哚酮(2-羟基吲哚);1,3-二氢-吲哚-2-酮;鄰胺苯乙酸內醯胺;2-羥吲哚;吲哚二酮

英文名称:

Oxindole

英文同义词:

OXINDOL;OXINDOLE;O-(AMINOPHENYL)ACETIC ACID LACTAM;TIMTEC-BB SBB004215;2-Oxo-2,3-dihydroindole;Indoline-2-one;NSC 274863;1,3-dihydro-2h-indol-2-on

CAS号:

59-48-3

分子式:

C8H7NO

分子量:

133.15

EINECS号:

200-429-5

相关类别:

吲哚类;硼酸系列;吲哚;细胞生物学;苯基硼酸类及衍生物系列;医药中间体;有机原料-酮;blocks;IndolesOxindoles;Aromatic Phenylacetic Acids and Derivatives;Indoles and derivatives;Indoline Oxindole;Indoles;Indole Derivatives;Heterocycle-Indole series;分析试剂标准品;生物碱;杂环化合物;有机化工原料

Mol文件:

59-48-3.mol

熔点 

123-128 °C(lit.)

沸点 

227 °C73 mm Hg(lit.)

密度 

1.1475 (rough estimate)

折射率 

1.5282 (estimate)

闪点 

194-196°C/17mm

储存条件 

Sealed in dry,Room Temperature

溶解度 

9.1g/l

酸度系数(pKa)

14.77±0.20(Predicted)

水溶解性 

insoluble

BRN 

114692

CAS 数据库

59-48-3(CAS DataBase Reference)

NIST化学物质信息

2H-Indol-2-one, 1,3-dihydro-(59-48-3)

EPA化学物质信息

Oxindol (59-48-3)

应用

2-吲哚酮为酮类衍生物，可用作医药中间体。

生物活性

Oxindole (2-indolone, 2-Oxindole, Indolin-2-one)是芳香族杂环有机化合物，当剂量过量时，可引起镇静、肌无力、低血压和昏迷。

体外研究

Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities.

化学性质 

白色或微黄色结晶粉末，熔点121-124°C。

用途 

医药中间体

危险品标志 

Xn

危险类别码 

22

安全说明 

22-24/25

危险品运输编号 

2811

WGK Germany 

3

RTECS号

NM2080500

HazardClass 

6.1(b)

PackingGroup 

III

海关编码 

29337900