中文同义词:
佐芬普利-D5;1-萘乙酸(NAA),FOR PLANT CELL CULTURE,≥96%;1-萘乙酸(NAA),96%;佐芬普利;佐芬普利杂质;4S-1-[D-3-(苯甲酰硫基)-2-甲基丙酰]-4-(苯硫基)-L-脯氨酸
英文同义词:
1-NAPHTHYLACETICACIDα-NAPHTHYLACETICACID;1-[(S)-3-(Benzoylthio)-2-methyl-1-oxopropyl]-4α-(phenylthio)-L-proline;S-Benzoyl-4-phenylthiocaptopril;(4S)-N-[3-(Benzoylsulfanyl)-2(S)-methylpropionyl]-4-(phenylsulfanyl)-L-proline;Zofenopril;NAA(R);NAA(TM);NAA
比旋光度
D25 -36.5° (c = 1 in methanol)
沸点
646.3±55.0 °C(Predicted)
密度
1.34±0.1 g/cm3(Predicted)
酸度系数(pKa)
pK1:4.236 (25°C)
CAS 数据库
81872-10-8(CAS DataBase Reference)
生物活性
Zofenopril 是一个 angiotensin-converting enzyme (ACE) 抑制剂，其 IC50 值为 81 μM。
体外研究
Kinetic analyses demonstrate that enalapril inhibits the uptake of GlySar in a competitive manner (K i approximately 6 mM). Fosinopril and Zofenopril have the greatest inhibitory potency (IC 50 values of 55 and 81μM, respectively) while the other ACE inhibitors exhibit low-affinity interactions with the renal peptide transporter.
体内研究
Zofenopril, a sulphydrylic compound, at doses higher than 70 mg/kg i.p. produces significant protection (i.e. at 70 mg/kg, P=0.044, F=2.17, d.f.=18; at higher concentration P<0.05) against the tonic phase of the audiogenic seizure response. Pretreatment with Zofenopril (15 mg/kg, i.p.) is able to produce a consistent shift to the left of the dose-response curves and a significant reduction of ED 50 values against clonus of some AEDs with the exceptions of diazepam, felbamate, phenobarbital and phenytoin compare with concurrent groups, suggesting an increase in anticonvulsant activity.
