中文名称:

BETA-岚香酮酸

中文同义词:

Β-岚香酮酸;Β-榄香酮酸;Β榄香酮酸;Β-岚香酮酸, 来源于橄榄;BETA-岚香酮酸;BETA-岚香酮酸、BETA-榄香酮酸;Β-ELEMONIC ACID;Β-榄香酮酸标准品

英文名称:

β-Elemonic Acid

英文同义词:

BETA-ELEMONIC ACID;Elemadienonic acid;Beta-EleMonic;3-OXOTIRUCALLA-8,24-DIEN-21-OIC ACID;β-deMonic acid;β-Elemonic acid, 98%, from Canarium album (Lour.) Raeusch.;(13α,14β,17α,20S)-3-Oxolanosta-8,24-dien-21-oic acid;B-ELEMONIC ACID

CAS号:

28282-25-9

分子式:

C30H46O3

分子量:

454.68

EINECS号:

300-005-5

相关类别:

标准品;中药对照品;对照品;植物提取物;对照品-中药对照品;标准品 -中药标准品;标准品，对照品;Tri-Terpenoids;reagent;standard substance;Triterpenoids

Mol文件:

28282-25-9.mol

熔点 

224-225°C

沸点 

565.2±50.0 °C(Predicted)

密度 

1.07

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

4.65±0.10(Predicted)

生物活性

β-Elemonic acid 是从乳香树中分离得到的三萜。β-Elemonic acid 诱导细胞凋亡，活性氧 (ROS) 和 COX-2 表达，并抑制脯氨酰内肽酶。β-Elemonic acid 具有抗癌和抗炎作用。

靶点

COX-2

COX-2

体外研究

β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC 50 value following a 24-h exposure to β-elemonic acid was 6.92 µM. β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于乳香。