中文名称:

醋酸普兰林肽

中文同义词:

醋酸普兰林肽;醋酸普蓝林肽;醋酸普兰林肽 PRAMLINTIDEACETATE;醋酸普兰林肽 196078-30-5;醋酸普兰林肽 醋酸普蓝林肽;醋酸普林兰肽;醋酸普兰林肽杂质;普林兰肽

英文名称:

Pramlintide acetate

英文同义词:

AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE;pramlintide acetate;pramlintide acetate hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;Pramlintide acetate fandachem

CAS号:

196078-30-5

分子式:

C173H273N51O56S2

分子量:

4027.46

EINECS号:

相关类别:

现货;原料药;医用原料;多肽;其他科研原料药;中间体;医药原料药;Peptide;Amino Acids Derivatives;Bases Related Reagents;Drug Analogues;Heterocycles;Intermediates Fine Chemicals;Nucleotides;Pharmaceuticals;多肽原料药;医药原料药 科研原料;医药原料;药物多肽

Mol文件:

196078-30-5.mol

CAS 数据库

196078-30-5(CAS DataBase Reference)

生物活性

Pramlintide acetate 是一种人胰淀粉样多肽类似物。Pramlintide acetate 是一种抗糖尿病剂，也可用于肠癌的研究。

体外研究

Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC 50 s of 48.67 and 9.10 μg/mL, respectively). The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically.