去铁铵
中文名称:
去铁铵
中文同义词:
甲磺酸去铁胺;甲磺酸去铁敏;甲磺酸除铁灵;去铁铵/去铁敏;DEFEROX胺甲磺酸盐;去铁胺甲磺酸盐;去铁铵;去铁胺甲磺酸酯
英文名称:
DEFEROXAMINE MESYLATE
英文同义词:
deferoxaminebmesylate;deferoxaminemesilate;deferoxaminemethanesulfonate;desferal;desferalmesylate;desferalmethanesulfonate;desferrioxaminebmesylate;Deferoxamine Mesylate (300 mg)
CAS号:
138-14-7
分子式:
C26H52N6O11S
分子量:
656.79
EINECS号:
205-314-3
相关类别:
医药中间体;小分子抑制剂;小分子抑制剂，天然产物;医药原料药-科研原料;医药原料;Inhibitors;DESFERAL;Aliphatics;Amines;Chelating Agents Ligands;Intermediates Fine Chemicals;Pharmaceuticals
Mol文件:
138-14-7.mol
熔点
148-149°
储存条件
2-8°C
溶解度
H2O: 50 mg/mL
形态
powder
颜色
white to off-white
生物活性
Deferoxamine mesylate (Desferrioxamine B, DFOM)是Deferoxamine的甲磺酸盐，它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂，可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。
靶点
Target Value
HIF-1α
()
Beta Amyloid
()
Ferroptosis
()
Target
Value
HIF-1α
()
Beta Amyloid
()
Ferroptosis
()
体外研究
Deferoxamine treatment significantly increases HIF-1α binding under all culture conditions, including hypoxic and high-glucose. The mechanism of deferoxamine is through improving HIF-1α biological function through scavenging oxygen free radicals. Deferoxamine (5 μM) has significant effect on the tumor-associated stromal cells cellular multiplication, and cells die at day 7 after exposure to 50 μM and 100 μM deferoxamine. Deferoxamine (5 μM-100 μM) inhibits the proliferation of BMMSCs, and induces apoptosis of MSCs in a dose-dependent manner. Deferoxamine influences the expression of adhesion proteins on MSCs. Deferoxamine (30, 60, 120 μM) shows lower expression of HIF-1α in a concentration dependent way in AdMSCs.
体内研究
Deferoxamine (100 mg/kg, i.p.) lowers the mortality rate of subarachnoid hemorrhage (SAH) rat. Deferoxamine (100 mg/kg, i.p.) attenuates Evan’s blue extravasation in cortex, ameliorates the tight junction detachment and preserves the integrity of the base membrane examined in electron microscope at day 3 after SAH. Deferoxamine attenuates degradation of BBB proteins after SAH and significantly reduces ferritin expression at day 3 in the cortex, and improves neurologic behavior and cognitive deficits after experimental. Ten µL of 1 mM deferoxamine-treated wounds display significantly accelerated healing from day 7 onward and heal significantly faster than control-treated wounds in diabetic mice. Deferoxamine-treated wounds and dimethyloxalylglycine-treated wounds heal significantly faster than control-treated wounds in aged mice. In deferoxamine (10 mg/mL)-treated TG mice, there is a decrease in both soluble and insoluble Aβ40 and Aβ42. Both pGSK3β and β-catenin are significantly increased by approximately 50% in the deferoxamine-treated mice.
安全说明
22-24/25
WGK Germany
2
RTECS号
UG5310000
海关编码
29280000
