中文名称:

CZC25146

中文同义词:

英文名称:

N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide

英文同义词:

CZC-25146;N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide;N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide;N-(2-((5-fluoro-2-((2-methoxy-4- morpholinophenyl)amino)pyrimidin- 4- yl)amino)phenyl)methanesulfonamide;LRRK2 Inhibitor II;LRRK2 INHIBITOR II;CZC25146;CZC 25146;CHEMBL2397014;Methanesulfonamide, N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-

CAS号:

1191911-26-8

分子式:

C22H25FN6O4S

分子量:

488.54

EINECS号:

相关类别:

Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates Fine Chemicals;API

Mol文件:

1191911-26-8.mol

沸点 

697.4±65.0 °C(Predicted)

密度 

1.436±0.06 g/cm3(Predicted)

储存条件 

Inert atmosphere,2-8°C

酸度系数(pKa)

8.48±0.10(Predicted)

生物活性

CZC-25146是一种有效、选择性的LRRK2抑制剂，对human wild type LRRK2和G2019S LRRK2的IC50分别为4.76 nM和6.87 nM。

靶点

Target Value human wild type LRRK2 (Cell-free assay) 4.76 nM G2019S LRRK2 (Cell-free assay) 6.87 nM

Target

Value

human wild type LRRK2 (Cell-free assay)

4.76 nM

G2019S LRRK2 (Cell-free assay)

6.87 nM

用途 

CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons鈥檚 disease, and is ATP-competitive.