英文同义词:
AM2394;1-(6-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3-bipyridin]-6-yl)-3-methylurea;AM2394;AM 2394;CS-2242;N-[6-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3-bipyridin]-6-yl]-N-methylurea;Urea, N-[6-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3-bipyridin]-6-yl]-N-methyl-
沸点
588.8±50.0 °C(Predicted)
密度
1.266±0.06 g/cm3(Predicted)
储存条件
Inert atmosphere,Room Temperature
酸度系数(pKa)
12.66±0.70(Predicted)
用途
AM 2394是一种结构独特的葡萄糖激酶激活剂(GKA)。AM-2394通过一个60 nM的EC50激活GK。
生物活性
AM-2394 是一种新型的 glucokinase 激活剂 (GKA)。AM-2394激活葡萄糖激酶 (GK)，EC50 为 60 nM。
靶点
EC50: 60 nM (glucokinase)
体内研究
AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.
