澳洲茄边碱

中文名称:

澳洲茄边碱

中文同义词:

澳洲茄边碱, >98%;Α-奥洲边茄碱;澳洲茄边碱(标准品);边缘茄碱;澳洲茄边碱(奥洲边茄碱);澳州茄边碱;Α-SOLAMARGINE

英文名称:

Solamargine

英文同义词:

SOLAMERGINE;Solamargine, >98%;Solamargine 20311-51-7;δ-Solanigrine;2)-O-[6-deoxy-a-L-Mannopyranosyl-(1®;b-D-Glucopyranoside, (3b,22a,25R)-spirosol-5-en-3-yl O-6-deoxy-a-L-Mannopyranosyl-(1®;(3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→2)-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside;[(22R,25R)-Spirosola-5-ene-3β-yl]2-O,4-O-bis(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

CAS号:

20311-51-7

分子式:

C45H73NO15

分子量:

868.06

EINECS号:

相关类别:

植物提取物;对照品;植提标准品;中药对照品;标准品;标准品-中药标准品;标准品 -中药标准品;Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品，对照品

Mol文件:

20311-51-7.mol

熔点

301 °C

密度

1.38

酸度系数(pKa)

12?+-.0.70(Predicted)

生物活性

Solamargine 是一种来源于茄属植物的类固醇 Solasodine 的衍生物，在多种癌症中均表现出抗癌活性。Solamargine 诱导非选择性细胞毒性和 P-gp 抑制作用。Solamargine 通过下调 MMP-2 和 MMP-9 的表达和活性来显着抑制 HepG2 细胞的迁移和侵袭。

体外研究

Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis. Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC 50 s are 9.21 and 19.88 μg/ml, respectively. Cell Viability Assay Cell Line: SMMC-7721cells Concentration: 15 μg/ml Incubation Time: 72 hours Result: Displayed a significant increase of sub-G1.

Cell Line:

SMMC-7721cells

Concentration:

15 μg/ml

Incubation Time:

72 hours

Result:

Displayed a significant increase of sub-G1.

体内研究

Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo. Animal Model: Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) Dosage: 10 mg/kg Administration: Intragastric administration; once daily for 8 days Result: Tumor growth was significantly inhibited .

Animal Model:

Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old)

Dosage:

10 mg/kg

Administration:

Intragastric administration; once daily for 8 days

Result:

Tumor growth was significantly inhibited .

化学性质

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于澳洲茄 Solanum aviculare Forst.果实。

用途

澳洲茄边碱具有治疗牛皮癣、皮肤瘙痒的作用。