中文同义词:
1-[4-(2-萘基)-2-嘧啶基]-4-哌啶甲胺;Β-联蛋白激动剂(WAY-262611);WAY-262611游离态
英文同义词:
1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611;MAY-262611;DKK1;4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]-;WAY-262611;1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine;1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine;Wnt/β-catenin
相关类别:
细胞生物学试剂;小分子抑制剂;小分子抑制剂，天然产物;抑制剂;Inhibitors
沸点
544.8±42.0 °C(Predicted)
密度
1.169±0.06 g/cm3(Predicted)
储存条件
Keep in dark place,Inert atmosphere,2-8°C
酸度系数(pKa)
10.13±0.29(Predicted)
生物活性
WAY-262611是 Wnt/β- 联蛋白激动剂，可增加骨形成速率，在 TCF- 荧光素酶测定实验中的 EC50 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。
靶点
EC50: 0.63 μM (β-Catenin)
体外研究
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
体内研究
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β -catenin pathway and most likely through inhibition of Dkk-1.
