中文名称:

DEBIO 0932

中文同义词:

HSP90抑制剂(DEBIO 0932)

英文名称:

Debio 0932 ,CUDC-305

英文同义词:

Debio 0932;Debio 0932 ,CUDC-305;CUDC-305 (DEBIO-0932 );CUDC-305;CS-1423;1H-Imidazo[4,5-c]pyridine-1-ethanamine, 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-

CAS号:

1061318-81-7

分子式:

C22H30N6O2S

分子量:

442.58

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1061318-81-7.mol

沸点 

654.8±65.0 °C(Predicted)

密度 

1.32±0.1 g/cm3(Predicted)

酸度系数(pKa)

10.02±0.19(Predicted)

用途 

一种HSP90(热休克蛋白90)抑制剂，对 HSP90α和 HSP90β的IC50值分别为100和103nM。Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance.