扑蛲灵
中文名称:
扑蛲灵
中文同义词:
恩波吡维铵;吡维铵;吡维氯铵;恩波酸吡维铵;扑蛲灵;WNT抑制剂(PYRVINIUM PAMOATE);双羟萘酸扑蛲宁 USP标准品;双[6-(二甲基氨基)-2-[2-(2,5-二甲基-1-苯基吡咯-3-基)乙烯基]-1-甲基喹啉]4,4-亚甲基双[3-羟基-2-萘甲酸酯
英文名称:
PYRVINIUM PAMOATE
英文同义词:
6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-quinoliniu;alnoxin;altolat;methyl-,saltwith4,4’-methylenebis(3-hydroxy-2-naphthoicacid)(2:1);molevac;neo-oxypate;pamovin;pirviniumpamoate
CAS号:
3546-41-6
分子式:
C75H70N6O6
分子量:
1151.39
EINECS号:
222-596-3
相关类别:
细胞生物学试剂;POVAN
Mol文件:
3546-41-6.mol
熔点
210-215° (softens at 190°)
沸点
829.27°C (rough estimate)
密度
1.0104 (rough estimate)
折射率
1.6400 (estimate)
储存条件
2-8°C
溶解度
DMSO: >10mg/mL
形态
powder
颜色
red
EPA化学物质信息
Pyrvinium pamoate (3546-41-6)
生物活性
Pyrvinium是一种驱虫剂，对蛲虫有效。
体外研究
Pyrvinium pamoate (0-500 nM) inhibits proliferation of MCF-7 (luminal), MDA-MB-231 (claudin-low), MDA-MB-468 (basal-like) and SkBr3 (HER2-OE) cells in a dose-dependent manner, with IC 50 value of 1170±105.0 nM against MDA-MB-231 cell line. Pyrvinium pamoate significantly inhibits self-renewal and proliferation of BCSCs, and suppresses BCSC population with a distinct phenotype. Pyrvinium pamoate significantly decreases average expression levels of FZD1, FZD10, WNT1, WNT7B, CTNNB1, MYC, and LRP5 at transcriptional level. Moreover, Pyrvinium pamoate also efficiently down-regulates the expression of other stemness genes including ALDH1, CD44 and ABCG2. Pyrvinium pamoate blocks colon cancer cell growth in vitro in a dose-dependent manner with great differences in the inhibitory concentration (IC 50 ), ranging from 0.6 to 65 μM for colon cancer cells with mutations in WNT signaling. Pyrvinium pamoate decreases messenger RNA (mRNA) and protein levels of known WNT target genes as c-MYC and thereby led to the induction of p21. Pyrvinium pamoate ultimately inhibits Wnt signalling despite its lack of efficacy on CK1. Pyrvinium pamoate imposes specific toxicity on cardiac fibroblasts in ischemia (IC 50 =9.5 nM). The cytotoxic effect of Pyrvinium pamoate on cardiac fibroblasts specifically under glucose- and glutamine-deficient condition.
体内研究
In the xenograft model, Pyrvinium pamoate (500 nM)-pretreatment strongly delays tumor size and tumor weight, and the tumor volume is markedly decreased.
危险品标志
Xn
危险类别码
20/21/22-36/37/38-40
安全说明
26-36
WGK Germany
3
海关编码
2933492250
