磺胺二甲嘧啶钠

中文名称:

磺胺二甲嘧啶钠

中文同义词:

N-(4,6-二甲基-2-嘧啶基)-4-氨基苯磺酰胺钠盐;磺胺二甲嘧啶钠;磺胺二甲嘧啶钠盐;2-(对氨基苯磺酰胺基)-4,6-二甲嘧啶钠;2-(对氨基苯磺酰胺基)-4,6-二甲嘧啶钠盐;磺胺二甲嘧啶鈉;磺胺二甲嘧啶钠(>99%,BP);磺胺二甲嘧啶钠盐,2-(对氨基苯磺酰胺基)-4,6-二甲嘧啶钠盐,2-(对氨基苯磺酰胺基)-4,6-二甲嘧啶钠

英文名称:

Sulfamethazine sodium salt

英文同义词:

(n(sup1)-(4,6-dimethyl-2-pyrimidinyl)sulfanilamido)-sodiu;4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamidmonosodiumsalt;sodiumsulphamezathine;sulfamethazinesodium;sulmet;vesadin;4-AMINO-N-[4,6-DIMETHYL-2-PYRIMIDINYL]BENZENE-SULFONAMIDE SODIUM SALT;SULFADIMIDINE SODIUM

CAS号:

1981-58-4

分子式:

C12H15N4NaO2S

分子量:

302.33

EINECS号:

217-840-0

相关类别:

磺胺类产品;生命科学标准品;磺胺类抗菌消炎药;分析标准品;生化试剂;抗生素;小分子抑制剂;小分子抑制剂，天然产物;嘧啶;Inhibitors;Animal medication;化合物：原料药;医药化工类;原料中间体-原料药;原料药;医药原料;有机化工原料;兽药原料;医用原料;医药原料药;API原料药-抗菌;原料;医药、农药及染料中间体;化工材料;Antibiotics for Research and Experimental Use;Biochemistry;Sulfonamides (Antibiotics for Research and Experimental Use);Pharmaceutical intermediate;API;sulfonamides

Mol文件:

1981-58-4.mol

储存条件 

2-8°C

溶解度 

H2O: soluble50mg/mL

形态

powder

颜色

white to off-white

Merck 

14,8915

CAS 数据库

1981-58-4

EPA化学物质信息

Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt (1981-58-4)

生物活性

Sulfamethazine (Sulfadimethyldiazine) 是磺胺类抗感染试剂，用于畜牧业。

靶点

Bacterial

体内研究

Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC 0->∞ , significantly increases t 1/2 α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01. Animal Model: 19 healthy female pigs (6-week-old, 4.5-6.2 kg) Dosage: 80 mg/kg Administration: Intravenous injection (Pharmacokinetic study) Result: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC 0->∞ were significantly decreased and t 1/2 α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.

Animal Model:

19 healthy female pigs (6-week-old, 4.5-6.2 kg)

Dosage:

80 mg/kg

Administration:

Intravenous injection (Pharmacokinetic study)

Result:

The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC 0->∞ were significantly decreased and t 1/2 α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.

用途 

磺胺类药，用于溶血性链球菌、肺炎球菌和脑膜炎球菌等感染

用途 

磺胺类药，用于脑膜炎、肺炎球菌、溶血性链球菌及某些革兰氏阴性杆菌所引起的感染。

用途 

一种抗菌磺胺药，诱导CYP3A4表达，以及通过N-乙酰转移酶乙酰化

危险品标志 

Xn

危险类别码 

22

安全说明 

36

WGK Germany 

3

RTECS号

WO9300000