双羟萘酸噻嘧啶

中文名称:

双羟萘酸噻嘧啶

中文同义词:

含 4,4′-亚甲基双(3-羟基-2-萘甲酸) 的 1-甲基-2-(2-[2-噻吩基]乙烯基)-1,4,5,6-四氢嘧啶化合物;恩波酸噻嘧啶;抗虫灵;双羟萘酸噻嘧啶(噻嘧啶);双羟萘酸噻嘧啶;抗虫灵、噻嘧啶;双羟萘酸噻嘧啶 标准品;双羟萘酸喹嘧啶

英文名称:

Pyrantel pamoate

英文同义词:

Pyrantel pamoate,1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4′-methylenebis(3-hydroxy-2-naphthoic acid);1,4,5,6-Tetrahydro-1-Methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyriMidine 4,4-Methylenebis[3-hydroxy-2-naphthalenecarboxylate];4,4-Methylenebis[3-hydroxy-2-naphthalenecarboxylic Acid coMpound with 1,4,5,6-Tetrahydro-1-Methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyriMidine;Early Bird;HelMintox;NeMocid;Piranver;Pyrantel paMoate bioxtra

CAS号:

22204-24-6

分子式:

C34H30N2O6S

分子量:

594.68

EINECS号:

244-837-1

相关类别:

原料;小分子抑制剂;医药原料药;中间体;抗生素;原料药;抗寄生虫病药;驱肠虫药;Veterinaries;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;NEMEX;医药原料;医药化工类;医用原料;化工原料;原料中间体-原料药;化工原料;医用原料;化学试剂

Mol文件:

22204-24-6.mol

熔点 

266-267°C

储存条件 

0-6°C

溶解度 

Pratically insoluble in water, soluble in dimethyl sulfoxide, pratically insoluble in methanol.

形态

powder

颜色

yellow

水溶解性 

<0.1 g/100 mL at 19 ºC

BRN 

9034755

EPA化学物质信息

2-Naphthalenecarboxylic acid, 4,4-methylenebis[3-hydroxy-, compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1) (22204-24-6)

生物活性

Pyrantel pamoate (Pyrantel Embonate)是一种广谱驱虫剂，用于治疗一些寄生虫感染。

体外研究

Pyrantel induces Ascaris suum muscle contraction, with a pEC 50 of 7.24. Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle. Pyrantel (72 h) inhibits the survival of Ancylostoma ceylanicum , Necator americanus and Trichuris muris on the third-stage larvae (IC 50 s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC 50 s=>100, 7.6, and 34.1 µg/mL, respectively).

体内研究

Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.

化学性质 

黄色至褐色晶体粉末

WGK Germany 

3

RTECS号

QL2287000

海关编码 

2934990002