L-甲状腺素

中文名称:

L-甲状腺素

中文同义词:

L-THYROXINE L-甲状腺素;L-甲状腺素/O-(4-羟基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸/3,5,3′,5′-四碘-L-甲状腺原氨酸/3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸/2-甲状腺素/L-Β-(3,5-二磺-4-羟基苯氧基)-3,5-二磺苯丙氨酸/左甲状腺素/T4;2-甲状腺素、左甲状腺素;L-甲壮腺素;L-甲状腺素(标准品);左甲状;3,5,3,5-四碘甲状腺胺酸;D-Α-生育酚

英文名称:

L-Thyroxine

英文同义词:

3,5,3’,5’-tetraiodothyronine;beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine;l-3,5,3’,5’-tetraiodothyronine;l-t4;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin;β-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine;3,5,3,5-TETRAIODO-L-THYRONINE;3,3,5,5-TETRAIODO-L-THYRONIN

CAS号:

51-48-9

分子式:

C15H11I4NO4

分子量:

776.87

EINECS号:

200-101-1

相关类别:

原料药;医药级;氨基酸;细胞生物学;兽药级;医药原料;杂环化合物;医药中间体;激素;生化试剂;生物化学品;原料;小分子抑制剂;小分子抑制剂，天然产物;饲料添加剂;Pyridines ,氟化学;氨基酸类;内分泌与激素;Amino Acids;Organics;Heterocyclic Compounds;Amino Acids Derivatives;Intermediates Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Aromatics;Isotope Labelled Compounds;SYNTHROID;Isolabel;Other APIs;Inhibitors;化合物;化学试剂;对照品;其他生化试剂;前列素系列;有机中间体;其他;中药对照品;化工原料;主营产品

Mol文件:

51-48-9.mol

熔点 

235 °C

比旋光度 

-5 º (1N NaOH:EtOH 1:2)

密度 

2.4440 (estimate)

闪点 

9℃

储存条件 

2-8°C

溶解度 

Dissolves in 4M ammonium hydroxide in Methanol at 50mg/ml

酸度系数(pKa)

2.2(at 25℃)

形态

Powder

沸点 

576.3±50.0 °C(Predicted)

颜色

White to Pale Brown

水溶解性 

insoluble

敏感性 

Light Sensitive

Merck 

9491

BRN 

2228515

InChIKey

XUIIKFGFIJCVMT-LBPRGKRZSA-N

CAS 数据库

51-48-9(CAS DataBase Reference)

EPA化学物质信息

L-Thyroxine (51-48-9)

生物活性

L-Thyroxine (NSC 36397)是甲状腺素的合成形式，是一种激素替代药物。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体内研究

Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).

化学性质 

白色结晶。Mp235-236℃(分解)，比旋光度[α]20D-4.4°(3%，0.13 mol/L 氢氧化钠，70%乙醇)，在0.4 mol/L NaOH溶液中325nm波长处有最大吸收、0.4mol/L HCl溶液中295nm波长处有最大吸收。本品溶于碱溶液，不溶于水、乙醇和乙醚。

用途 

生化研究；拟甲状腺素药物。

用途 

L- 甲状腺素 (T4) 和三吲哚-L-甲状腺原氨酸(triiodo-L-thyronine，T3) 是含吲哚激素，是由甲状腺滤泡细胞里的甲状腺球蛋白产生的。L-甲状腺素通过影响DNA转录和蛋白质合成来刺激代谢和调控生长和发育。

生产方法 

以3，5-二碘-L-酪氨酸为主要原料。

危险品标志 

Xn,T,F

危险类别码 

40-39/23/24/25-23/24/25-11

安全说明 

22-24/25-36-45-36/37-16

危险品运输编号 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

3

RTECS号

YP2833500

F 

8-10

TSCA 

Yes

HazardClass 

IRRITANT

海关编码 

29379000

毒害物质数据

51-48-9(Hazardous Substances Data)

毒性

TDLo oral in child: 328ug/kg